1W70
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![BU of 1w70 by Molmil](/molmil-images/mine/1w70) | SH3 domain of p40phox complexed with C-terminal polyProline region of p47phox | Descriptor: | NEUTROPHIL CYTOSOL FACTOR 1, NEUTROPHIL CYTOSOL FACTOR 4, SULFATE ION, ... | Authors: | Massenet, C, Chenavas, S, Cohen-Addad, C, Dagher, M.-C, Brandolin, G, Pebay-Peyroula, E, Fieschi, F. | Deposit date: | 2004-08-26 | Release date: | 2005-01-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Effects of P47Phox C-Terminus Phosphorylation on Binding Interactions with P40Phox and P67Phox: Structural and Functional Comparison of P40Phox P67Phox SH3 Domains J.Biol.Chem., 280, 2005
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1EI0
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8VXE
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![BU of 8vxe by Molmil](/molmil-images/mine/8vxe) | Structure of p38 alpha (Mitogen-activated protein kinase 14) complexed with inhibitor 6 | Descriptor: | (4M)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine, Mitogen-activated protein kinase 14 | Authors: | Blaesse, M, Steinbacher, S, Shaffer, P.L, Sharma, S, Thompson, A.A. | Deposit date: | 2024-02-04 | Release date: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure-Based Optimization of Selective and Brain Penetrant CK1 delta Inhibitors for the Treatment of Circadian Disruptions. Acs Med.Chem.Lett., 15, 2024
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4UHP
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![BU of 4uhp by Molmil](/molmil-images/mine/4uhp) | Crystal structure of the pyocin AP41 DNase-Immunity complex | Descriptor: | BACTERIOCIN IMMUNITY PROTEIN, LARGE COMPONENT OF PYOCIN AP41 | Authors: | Joshi, A, Chen, S, Wojdyla, J.A, Kaminska, R, Kleanthous, C. | Deposit date: | 2015-03-25 | Release date: | 2015-08-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the Ultra-High Affinity Protein-Protein Complexes of Pyocins S2 and Ap41 and Their Cognate Immunity Proteins from Pseudomonas Aeruginosa J.Mol.Biol., 427, 2015
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7Z4W
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![BU of 7z4w by Molmil](/molmil-images/mine/7z4w) | gp6/gp15/gp16 connector complex of bacteriophage SPP1 | Descriptor: | Head completion protein gp15, Head completion protein gp16, Portal protein | Authors: | Orlov, I, Roche, S, Tavares, P, Orlova, E.V. | Deposit date: | 2022-03-05 | Release date: | 2022-11-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | CryoEM structure and assembly mechanism of a bacterial virus genome gatekeeper. Nat Commun, 13, 2022
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4UHQ
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![BU of 4uhq by Molmil](/molmil-images/mine/4uhq) | Crystal structure of the pyocin AP41 DNase | Descriptor: | CITRIC ACID, LARGE COMPONENT OF PYOCIN AP41, NICKEL (II) ION | Authors: | Joshi, A, Chen, S, Wojdyla, J.A, Kaminska, R, Kleanthous, C. | Deposit date: | 2015-03-25 | Release date: | 2015-08-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structures of the Ultra-High Affinity Protein-Protein Complexes of Pyocins S2 and Ap41 and Their Cognate Immunity Proteins from Pseudomonas Aeruginosa J.Mol.Biol., 427, 2015
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7ZGU
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![BU of 7zgu by Molmil](/molmil-images/mine/7zgu) | Human NLRP3-deltaPYD hexamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 3 | Authors: | Raisch, T, Machtens, D.A, Bresch, I.B, Eberhage, J, Prumbaum, D, Reubold, T.F, Raunser, S, Eschenburg, S. | Deposit date: | 2022-04-04 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of the NEK7-independent NLRP3 inflammasome To Be Published
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1W6X
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![BU of 1w6x by Molmil](/molmil-images/mine/1w6x) | SH3 domain of p40phox, component of the NADPH oxidase | Descriptor: | NEUTROPHIL CYTOSOL FACTOR 4 | Authors: | Massenet, C, Chenavas, S, Cohen-Addad, C, Dagher, M.-C, Brandolin, G, Pebay-Peyroula, E, Fieschi, F. | Deposit date: | 2004-08-24 | Release date: | 2005-01-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Effects of P47Phox C-Terminus Phosphorylation on Binding Interactions with P40Phox and P67Phox: Structural and Functional Comparison of P40Phox P67Phox SH3 Domains J.Biol.Chem., 280, 2005
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6EO1
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![BU of 6eo1 by Molmil](/molmil-images/mine/6eo1) | The electron crystallography structure of the cAMP-bound potassium channel MloK1 (PCO-refined) | Descriptor: | Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION | Authors: | Kowal, J, Biyani, N, Chami, M, Scherer, S, Rzepiela, A, Baumgartner, P, Upadhyay, V, Nimigean, C, Stahlberg, H. | Deposit date: | 2017-10-08 | Release date: | 2017-12-27 | Last modified: | 2024-05-15 | Method: | ELECTRON CRYSTALLOGRAPHY (4.5 Å) | Cite: | High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer. Structure, 26, 2018
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8WJY
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![BU of 8wjy by Molmil](/molmil-images/mine/8wjy) | PKMYT1_Cocrystal_Cpd 4 | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, ... | Authors: | Wang, Y, Wang, C, Liu, T, Qi, H, Chen, S, Cai, X, Zhang, M, Aliper, A, Ren, F, Ding, X, Zhavoronkov, A. | Deposit date: | 2023-09-26 | Release date: | 2023-11-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer. J.Med.Chem., 67, 2024
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8W0Q
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![BU of 8w0q by Molmil](/molmil-images/mine/8w0q) | Pembrolizumab CDR-H3 Loop Mimic | Descriptor: | Pembrolizumab CDR-H3 Loop Mimic | Authors: | Feig, M, Roche, S.P. | Deposit date: | 2024-02-14 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | SOLUTION NMR | Cite: | De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics. Acs Chem.Biol., 2024
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6JYV
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![BU of 6jyv by Molmil](/molmil-images/mine/6jyv) | Structure of an isopenicillin N synthase from Pseudomonas aeruginosa PAO1 | Descriptor: | Probable iron/ascorbate oxidoreductase, SODIUM ION | Authors: | Hao, Z, Che, S, Wang, R, Liu, R, Zhang, Q, Bartlam, M. | Deposit date: | 2019-04-28 | Release date: | 2019-05-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Structural characterization of an isopenicillin N synthase family oxygenase from Pseudomonas aeruginosa PAO1. Biochem.Biophys.Res.Commun., 514, 2019
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1MZP
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![BU of 1mzp by Molmil](/molmil-images/mine/1mzp) | Structure of the L1 protuberance in the ribosome | Descriptor: | 50s ribosomal protein L1P, MAGNESIUM ION, fragment of 23S rRNA | Authors: | Nikulin, A, Eliseikina, I, Tishchenko, S, Nevskaya, N, Davydova, N, Platonova, O, Piendl, W, Selmer, M, Liljas, A, Zimmermann, R, Garber, M, Nikonov, S. | Deposit date: | 2002-10-09 | Release date: | 2003-01-21 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structure of the L1 protuberance in the ribosome. Nat.Struct.Biol., 10, 2003
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8JMP
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![BU of 8jmp by Molmil](/molmil-images/mine/8jmp) | Structure of a leaf-branch compost cutinase, ICCG in complex with 1,4-butanediol terephthalate | Descriptor: | 4-[4-(4-carboxyphenyl)carbonyloxybutoxycarbonyl]benzoic acid, CALCIUM ION, Leaf-branch compost cutinase | Authors: | Yang, Y, Xue, T, Zheng, Y, Cheng, S, Guo, R.-T, Chen, C.-C. | Deposit date: | 2023-06-05 | Release date: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Remodeling the polymer-binding cavity to improve the efficacy of PBAT-degrading enzyme. J Hazard Mater, 464, 2023
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8JMO
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![BU of 8jmo by Molmil](/molmil-images/mine/8jmo) | Structure of a leaf-branch compost cutinase, ICCG in complex with 4-((4-Hydroxybutoxy)carbonyl)benzoic acid | Descriptor: | 4-(4-oxidanylbutoxycarbonyl)benzoic acid, CALCIUM ION, Leaf-branch compost cutinase | Authors: | Yang, Y, Xue, T, Zheng, Y, Cheng, S, Guo, R.-T, Chen, C.-C. | Deposit date: | 2023-06-05 | Release date: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Remodeling the polymer-binding cavity to improve the efficacy of PBAT-degrading enzyme. J Hazard Mater, 464, 2023
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7Y72
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![BU of 7y72 by Molmil](/molmil-images/mine/7y72) | SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 (focused refinement on Fab-RBD interface) | Descriptor: | Fab E7 heavy chain, Fab E7 light chain, Spike glycoprotein | Authors: | Chia, W.N, Tan, C.W, Tan, A.W.K, Young, B, Starr, T.N, Lopez, E, Fibriansah, G, Barr, J, Cheng, S, Yeoh, A.Y.Y, Yap, W.C, Lim, B.L, Ng, T.S, Sia, W.R, Zhu, F, Chen, S, Zhang, J, Greaney, A.J, Chen, M, Au, G.G, Paradkar, P, Peiris, M, Chung, A.W, Bloom, J.D, Lye, D, Lok, S.M, Wang, L.F. | Deposit date: | 2022-06-21 | Release date: | 2023-08-02 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor. Sci Adv, 9, 2023
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7Y71
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![BU of 7y71 by Molmil](/molmil-images/mine/7y71) | SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab E7 heavy chain, ... | Authors: | Chia, W.N, Tan, C.W, Tan, A.W.K, Young, B, Starr, T.N, Lopez, E, Fibriansah, G, Barr, J, Cheng, S, Yeoh, A.Y.Y, Yap, W.C, Lim, B.L, Ng, T.S, Sia, W.R, Zhu, F, Chen, S, Zhang, J, Greaney, A.J, Chen, M, Au, G.G, Paradkar, P, Peiris, M, Chung, A.W, Bloom, J.D, Lye, D, Lok, S.M, Wang, L.F. | Deposit date: | 2022-06-21 | Release date: | 2023-08-02 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor. Sci Adv, 9, 2023
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7P0H
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![BU of 7p0h by Molmil](/molmil-images/mine/7p0h) | Crystal structure of Helicobacter pylori ComF fused to an artificial alphaREP crystallization helper(named B2) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, GLYCEROL, Helicobacter pylori ComF fused to an artificial alphaREP crystallization helper (named B2), ... | Authors: | Celma, L, Walbott, H, Legrand, P, Quevillon-Cheruel, S. | Deposit date: | 2021-06-29 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | ComFC mediates transport and handling of single-stranded DNA during natural transformation. Nat Commun, 13, 2022
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1H69
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![BU of 1h69 by Molmil](/molmil-images/mine/1h69) | CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE CO WITH 2,3,5,6,TETRAMETHYL-P-BENZOQUINONE (DUROQUINONE) AT 2.5 ANGSTROM RESOLUTION | Descriptor: | 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE, FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H DEHYDROGENASE [QUINONE] 1 | Authors: | Faig, M, Bianchet, M.A, Chen, S, Winski, S, Ross, D, Amzel, L.M. | Deposit date: | 2001-06-08 | Release date: | 2001-09-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure-Based Development of Anticancer Drugs: Complexes of Nad(P)H:Quinone Oxidoreductase 1 with Chemotherapeutic Quinones Structure, 9, 2001
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7OMT
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![BU of 7omt by Molmil](/molmil-images/mine/7omt) | Crystal structure of ProMacrobody 21 with bound maltose | Descriptor: | HEXAETHYLENE GLYCOL, MAGNESIUM ION, ProMacrobody 21, ... | Authors: | Botte, M, Ni, D, Schenck, S, Zimmermann, I, Chami, M, Bocquet, N, Egloff, P, Bucher, D, Trabuco, M, Cheng, R.K.Y, Brunner, J.D, Seeger, M.A, Stahlberg, H, Hennig, M. | Deposit date: | 2021-05-24 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation. Nat Commun, 13, 2022
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7OMM
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![BU of 7omm by Molmil](/molmil-images/mine/7omm) | Cryo-EM structure of N. gonorhoeae LptDE in complex with ProMacrobodies (MBPs have not been built de novo) | Descriptor: | LPS-assembly lipoprotein LptE, LPS-assembly protein LptD, ProMacrobody 21,Maltodextrin-binding protein, ... | Authors: | Botte, M, Ni, D, Schenck, S, Zimmermann, I, Chami, M, Bocquet, N, Egloff, P, Bucher, D, Trabuco, M, Cheng, R.K.Y, Brunner, J.D, Seeger, M.A, Stahlberg, H, Hennig, M. | Deposit date: | 2021-05-24 | Release date: | 2022-05-04 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation. Nat Commun, 13, 2022
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8P34
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![BU of 8p34 by Molmil](/molmil-images/mine/8p34) | Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT | Descriptor: | Microtubule-associated protein tau | Authors: | Schweighauser, M, Garringer, H.J, Klingstedt, T, Masuda-Suzukake, M, Murrell, J.R, Vidal, R, Scheres, S.H.W, Goedert, M, Ghetti, B, Newell, K.L. | Deposit date: | 2023-05-17 | Release date: | 2023-07-05 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Mutation ∆K281 in MAPT causes Pick's disease. Acta Neuropathol, 146, 2023
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8OW0
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![BU of 8ow0 by Molmil](/molmil-images/mine/8ow0) | Cryo-EM structure of CBF1-CCAN bound topologically to a centromeric CENP-A nucleosome | Descriptor: | C0N3 DNA, Centromere-binding protein 1, Histone H2A.1, ... | Authors: | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | Deposit date: | 2023-04-26 | Release date: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
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8OW1
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![BU of 8ow1 by Molmil](/molmil-images/mine/8ow1) | Cryo-EM structure of the yeast Inner kinetochore bound to a CENP-A nucleosome. | Descriptor: | C0N3, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... | Authors: | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | Deposit date: | 2023-04-26 | Release date: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
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8ORF
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![BU of 8orf by Molmil](/molmil-images/mine/8orf) | |