8P34

Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT

Summary for 8P34

Entry DOI	10.2210/pdb8p34/pdb
EMDB information	17383
Descriptor	Microtubule-associated protein tau (1 entity in total)
Functional Keywords	deltak281, tau, amyloid filament, cross-beta-sheet, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	10135.67
Authors	Schweighauser, M.,Garringer, H.J.,Klingstedt, T.,Masuda-Suzukake, M.,Murrell, J.R.,Vidal, R.,Scheres, S.H.W.,Goedert, M.,Ghetti, B.,Newell, K.L. (deposition date: 2023-05-17, release date: 2023-07-05, Last modification date: 2023-07-19)
Primary citation	Schweighauser, M.,Garringer, H.J.,Klingstedt, T.,Nilsson, K.P.R.,Masuda-Suzukake, M.,Murrell, J.R.,Risacher, S.L.,Vidal, R.,Scheres, S.H.W.,Goedert, M.,Ghetti, B.,Newell, K.L. Mutation ∆K281 in MAPT causes Pick's disease. Acta Neuropathol, 146:211-226, 2023 Cited by PubMed: 37351604 DOI: 10.1007/s00401-023-02598-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.61 Å)

Structure validation