8P34
Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT
Summary for 8P34
| Entry DOI | 10.2210/pdb8p34/pdb |
| EMDB information | 17383 |
| Descriptor | Microtubule-associated protein tau (1 entity in total) |
| Functional Keywords | deltak281, tau, amyloid filament, cross-beta-sheet, protein fibril |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 10135.67 |
| Authors | Schweighauser, M.,Garringer, H.J.,Klingstedt, T.,Masuda-Suzukake, M.,Murrell, J.R.,Vidal, R.,Scheres, S.H.W.,Goedert, M.,Ghetti, B.,Newell, K.L. (deposition date: 2023-05-17, release date: 2023-07-05, Last modification date: 2024-07-24) |
| Primary citation | Schweighauser, M.,Garringer, H.J.,Klingstedt, T.,Nilsson, K.P.R.,Masuda-Suzukake, M.,Murrell, J.R.,Risacher, S.L.,Vidal, R.,Scheres, S.H.W.,Goedert, M.,Ghetti, B.,Newell, K.L. Mutation ∆K281 in MAPT causes Pick's disease. Acta Neuropathol, 146:211-226, 2023 Cited by PubMed Abstract: Two siblings with deletion mutation ∆K281 in MAPT developed frontotemporal dementia. At autopsy, numerous inclusions of hyperphosphorylated 3R Tau were present in neurons and glial cells of neocortex and some subcortical regions, including hippocampus, caudate/putamen and globus pallidus. The inclusions were argyrophilic with Bodian silver, but not with Gallyas-Braak silver. They were not labelled by an antibody specific for tau phosphorylated at S262 and/or S356. The inclusions were stained by luminescent conjugated oligothiophene HS-84, but not by bTVBT4. Electron cryo-microscopy revealed that the core of tau filaments was made of residues K254-F378 of 3R Tau and was indistinguishable from that of Pick's disease. We conclude that MAPT mutation ∆K281 causes Pick's disease. PubMed: 37351604DOI: 10.1007/s00401-023-02598-6 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.61 Å) |
Structure validation
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