1H69

CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE CO WITH 2,3,5,6,TETRAMETHYL-P-BENZOQUINONE (DUROQUINONE) AT 2.5 ANGSTROM RESOLUTION

Summary for 1H69

Entry DOI	10.2210/pdb1h69/pdb
Related	1D4A 1DXO 1H66 1QBG
Descriptor	NAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE, 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE, ... (4 entities in total)
Functional Keywords	flavoprotein, rossmann fold, oxidoreductase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P15559
Total number of polymer chains	4
Total formula weight	127425.08
Authors	Faig, M.,Bianchet, M.A.,Chen, S.,Winski, S.,Ross, D.,Amzel, L.M. (deposition date: 2001-06-08, release date: 2001-09-05, Last modification date: 2023-12-13)
Primary citation	Faig, M.,Bianchet, M.A.,Winski, S.,Hargreaves, R.,Moody, C.J.,Hudnott, A.R.,Ross, D.,Amzel, L.M. Structure-Based Development of Anticancer Drugs: Complexes of Nad(P)H:Quinone Oxidoreductase 1 with Chemotherapeutic Quinones Structure, 9:659-, 2001 Cited by PubMed: 11587640 DOI: 10.1016/S0969-2126(01)00636-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation