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Crystal structure of the single-stranded DNA binding protein from Mycobacterium leprae (Form II)
分子名称:	Single-stranded DNA-binding protein
著者	Kaushal, P.S, Singh, P, Sharma, A, Muniyappa, K, Vijayan, M.
登録日	2010-03-10
公開日	2010-10-06
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	X-ray and molecular-dynamics studies on Mycobacterium leprae single-stranded DNA-binding protein and comparison with other eubacterial SSB structures Acta Crystallogr.,Sect.D, 66, 2010

3AFP

Crystal structure of the single-stranded DNA binding protein from Mycobacterium leprae (Form I)
分子名称:	CADMIUM ION, GLYCEROL, Single-stranded DNA-binding protein
著者	Kaushal, P.S, Singh, P, Sharma, A, Muniyappa, K, Vijayan, M.
登録日	2010-03-10
公開日	2010-10-06
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	X-ray and molecular-dynamics studies on Mycobacterium leprae single-stranded DNA-binding protein and comparison with other eubacterial SSB structures Acta Crystallogr.,Sect.D, 66, 2010

6L4Z

Crystal structure of Zika NS2B-NS3 protease with compound 6
分子名称:	4-(hydroxymethyl)benzoic acid, Genome polyprotein
著者	Quek, J.P.
登録日	2019-10-21
公開日	2020-07-15
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease. Antiviral Res., 175, 2020

6L50

Crystal structure of Zika NS2B-NS3 protease with compound 16
分子名称:	2-sulfanylidene-1,3-thiazolidin-4-one, NS3 protease, Serine protease subunit NS2B
著者	Quek, J.P.
登録日	2019-10-21
公開日	2020-07-15
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease. Antiviral Res., 175, 2020

8JVE

Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer
分子名称:	1,2-ETHANEDIOL, 1-(3-methoxyphenyl)-1,2,3,4-tetrazole, Ubiquitin-conjugating enzyme E2 T
著者	Anantharajan, J, Baburajendran, N.
登録日	2023-06-28
公開日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.76 Å)
主引用文献	Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer. Biochem.Biophys.Res.Commun., 689, 2023

8JVL

Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer
分子名称:	1,2-ETHANEDIOL, 1-(4-methoxyphenyl)-1,2,3,4-tetrazole, Ubiquitin-conjugating enzyme E2 T
著者	Anantharajan, J, Baburajendran, N.
登録日	2023-06-28
公開日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.06 Å)
主引用文献	Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer. Biochem.Biophys.Res.Commun., 689, 2023

8JVD

Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening
分子名称:	5-fluoranyl-1,3-benzoxazol-2-amine, Ubiquitin-conjugating enzyme E2 T
著者	Anantharajan, J, Baburajendran, N.
登録日	2023-06-28
公開日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.696 Å)
主引用文献	Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening. Protein Sci., 33, 2024

8JUC

Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening
分子名称:	1,2-ETHANEDIOL, 7-methyl-2-(trifluoromethyl)-3~{H}-[1,2,4]triazolo[1,5-a]pyridin-5-one, Ubiquitin-conjugating enzyme E2 T
著者	Anantharajan, J, Baburajendran, N.
登録日	2023-06-26
公開日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.54 Å)
主引用文献	Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening. Protein Sci., 33, 2024

5GJ4

Structure of NS2B-NS3 Protease from Zika Virus caught after self-cleavage
分子名称:	CHLORIDE ION, Serine protease NS3, Serine protease subunit NS2B
著者	Phoo, W.W, Li, Y.
登録日	2016-06-27
公開日	2016-10-26
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.839 Å)
主引用文献	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage. Nat Commun, 7, 2016

5H4I

Unlinked NS2B-NS3 Protease from Zika Virus in complex with a compound fragment
分子名称:	ACETATE ION, NS2B cofactor, NS3 protease, ...
著者	Zhang, Z.Z, Li, Y.
登録日	2016-10-31
公開日	2016-12-14
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.004 Å)
主引用文献	Crystal structure of unlinked NS2B-NS3 protease from Zika virus Science, 354, 2016

5GPI

Crystal Structures of Unlinked NS2B-NS3 Protease from Zika Virus and Its Complex with a Reverse Peptide Inhibitor
分子名称:	NS2B cofactor, NS3 protease
著者	Phoo, W.W, Zhang, Z.Z.
登録日	2016-08-02
公開日	2016-12-14
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.578 Å)
主引用文献	Crystal structure of unlinked NS2B-NS3 protease from Zika virus Science, 354, 2016

5H6V

Structure of Zika virus protease in complex with a dipeptide inhibitor
分子名称:	(S)-2-acetamido-6-amino-N-((S)-5-guanidino-1-oxopentan-2-yl)hexanamide, Genome polyprotein
著者	Zhang, Z, Chen, M.
登録日	2016-11-15
公開日	2017-06-14
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.422 Å)
主引用文献	Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors Structure, 25, 2017

5Y41

Crystal Structure of LIGAND-BOUND NURR1-LBD
分子名称:	(13E,15S)-15-hydroxy-9-oxoprosta-10,13-dien-1-oic acid, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者	Sreekanth, R, Lescar, J, Yoon, H.S.
登録日	2017-07-31
公開日	2018-12-26
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nat.Chem.Biol., 2020

5YOF

Crystal structure of zika virus NS3 protease in complex with a dipeptide inhibitor
分子名称:	(S)-2-acetamido-6-amino-N-((S)-5-guanidino-1-oxopentan-2-yl)hexanamide, NS2B cofactor, NS3 Protease
著者	Phoo, W.W, Zhang, Z.Z.
登録日	2017-10-27
公開日	2018-03-21
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.51 Å)
主引用文献	Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor Structure, 26, 2018

5YOD

Crystal structure of zika virus NS3 protease in complex with a small molecule inhibitor
分子名称:	BENZOIC ACID, NS2B cofactor, NS3 protease
著者	Phoo, W.W, Zhang, Z.Z.
登録日	2017-10-27
公開日	2018-03-21
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor Structure, 26, 2018

6JM9

cryo-EM structure of DOT1L bound to unmodified nucleosome
分子名称:	DNA strand I, DNA strand J, Histone H2A, ...
著者	Jang, S, Song, J.J.
登録日	2019-03-07
公開日	2019-05-15
最終更新日	2024-03-27
実験手法	ELECTRON MICROSCOPY (7.3 Å)
主引用文献	Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase. Genes Dev., 33, 2019

6JMA

cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome
分子名称:	DNA I&J, Histone H2A, Histone H2B 1.1, ...
著者	Jang, S, Song, J.J.
登録日	2019-03-07
公開日	2019-05-15
最終更新日	2024-03-27
実験手法	ELECTRON MICROSCOPY (6.8 Å)
主引用文献	Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase. Genes Dev., 33, 2019

7VW5

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
分子名称:	MAGNESIUM ION, RNA-directed RNA polymerase nsP4
著者	Tan, Y.B, Luo, D.
登録日	2021-11-09
公開日	2022-02-16
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Nucleic Acids Res., 50, 2022

7VB4

A crystal structure of alphavirus nonstructural protein 4 (nsP4) reveals an intrinsically dynamic RNA-dependent RNA polymerase
分子名称:	GLYCEROL, MAGNESIUM ION, RNA-directed RNA polymerase nsP4
著者	Tan, Y.B, Luo, D.
登録日	2021-08-30
公開日	2022-02-16
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.86 Å)
主引用文献	Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Nucleic Acids Res., 50, 2022

5BOC

Crystal structure of topoisomerase ParE inhibitor
分子名称:	3-methyl-4-({3-[3-methyl-5-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)benzoic acid, DNA topoisomerase 4 subunit B
著者	Tan, Y.W, Chen, G.Y, Hung, A.W, Hill, J.
登録日	2015-05-27
公開日	2015-06-17
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Application of Fragment-based Drug Discovery against DNA GyraseB To be published

5BOD

Crystal structure of Streptococcus pneumonia ParE inhibitor
分子名称:	(2R)-N-[3-(3,5-dimethylphenyl)-1H-pyrazol-5-yl]-1,4-dioxane-2-carboxamide, DNA topoisomerase 4 subunit B
著者	Tan, Y.W, Chen, G, Hung, A.W, Hill, J.
登録日	2015-05-27
公開日	2015-06-17
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Application of Fragment-based Drug Discovery against DNA GyraseB to be published

2LAV

NMR solution structure of human Vaccinia-Related Kinase 1
分子名称:	Vaccinia-related kinase 1
著者	Shin, J, Yoon, H.S.
登録日	2011-03-21
公開日	2011-05-04
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	NMR Solution Structure of Human Vaccinia-related Kinase 1 (VRK1) Reveals the C-terminal Tail Essential for Its Structural Stability and Autocatalytic Activity. J.Biol.Chem., 286, 2011

5DQE

Crystal structure of human transcription factor TEAD2 in complex with bromo-fenamic acid
分子名称:	2-[(3-bromophenyl)amino]benzoic acid, Transcriptional enhancer factor TEF-4
著者	Han, X, Luo, X.
登録日	2015-09-14
公開日	2015-11-25
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.183 Å)
主引用文献	Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure, 23, 2015

2MHF

Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel
分子名称:	Uncharacterized protein
著者	Li, Q, Ng, H.
登録日	2013-11-21
公開日	2014-04-02
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel. J.Struct.Biol., 186, 2014

5DQ8

Crystal structure of human transcription factor TEAD2 in complex with flufenamic acid
分子名称:	2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, Transcriptional enhancer factor TEF-4
著者	Han, X, Luo, X.
登録日	2015-09-14
公開日	2015-11-25
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.305 Å)
主引用文献	Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure, 23, 2015

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