8JVE

Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer

Summary for 8JVE

Entry DOI	10.2210/pdb8jve/pdb
Descriptor	Ubiquitin-conjugating enzyme E2 T, 1-(3-methoxyphenyl)-1,2,3,4-tetrazole, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	ube2t, drug discovery, covalent inhibitor, fanconi anemia, ligase-inhibitor complex, ligase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	18068.84
Authors	Anantharajan, J.,Baburajendran, N. (deposition date: 2023-06-28, release date: 2023-11-29)
Primary citation	Anantharajan, J.,Tan, Q.W.,Fulwood, J.,Sifang, W.,Huang, Q.,Ng, H.Q.,Koh, X.,Xu, W.,Cherian, J.,Baburajendran, N.,Kang, C.,Ke, Z. Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer. Biochem.Biophys.Res.Commun., 689:149238-149238, 2023 Cited by PubMed: 37979329 DOI: 10.1016/j.bbrc.2023.149238 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation