5YOF

Crystal structure of zika virus NS3 protease in complex with a dipeptide inhibitor

Summary for 5YOF

• Entry DOI: 10.2210/pdb5yof/pdb
• Descriptor: NS2B cofactor, NS3 Protease, (S)-2-acetamido-6-amino-N-((S)-5-guanidino-1-oxopentan-2-yl)hexanamide, ... (4 entities in total)
• Functional Keywords: serine protease, viral non-structural protein, zika virus protease, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Zika virus; More
• Total number of polymer chains: 2
• Total formula weight: 25215.32

Authors

Phoo, W.W.,Zhang, Z.Z. (deposition date: 2017-10-27, release date: 2018-03-21, Last modification date: 2023-11-22)

• Primary citation: Li, Y.,Zhang, Z.,Phoo, W.W.,Loh, Y.R.,Li, R.,Yang, H.Y.,Jansson, A.E.,Hill, J.,Keller, T.H.,Nacro, K.,Luo, D.,Kang, C.; Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor; Structure, 26:555-564.e3, 2018; PubMed: 29526431; DOI: 10.1016/j.str.2018.02.005

Experimental method

X-RAY DIFFRACTION (1.51 Å)