6JMA

cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome

Summary for 6JMA

• Entry DOI: 10.2210/pdb6jma/pdb
• EMDB information: 9843 9844
• Descriptor: DNA I&J, Histone H3.2, Histone H4, ... (8 entities in total)
• Functional Keywords: histone, nucleosome, methylation, gene regulation
• Biological source: synthetic construct; More
• Total number of polymer chains: 12
• Total formula weight: 206478.26

Authors

Jang, S.,Song, J.J. (deposition date: 2019-03-07, release date: 2019-05-15, Last modification date: 2024-03-27)

• Primary citation: Jang, S.,Kang, C.,Yang, H.S.,Jung, T.,Hebert, H.,Chung, K.Y.,Kim, S.J.,Hohng, S.,Song, J.J.; Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.; Genes Dev., 33:620-625, 2019; PubMed: 30923167; DOI: 10.1101/gad.323790.118

Experimental method

ELECTRON MICROSCOPY (6.8 Å)