6JMA
cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (I, J) | DNA I&J | polymer | 114 | 35168.5 | 2 | synthetic construct | ||
| 2 | C, G (A, E) | Histone H3.2 | polymer | 98 | 11488.4 | 2 | UniProt (P84233) Pfam (PF00125) | Xenopus laevis (African clawed frog) | |
| 3 | D, H (B, F) | Histone H4 | polymer | 87 | 9990.8 | 2 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 4 | E, I (C, G) | Histone H2A | polymer | 116 | 12660.7 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) | Xenopus laevis (African clawed frog) | |
| 5 | F, J (D, H) | Histone H2B 1.1 | polymer | 94 | 10478.0 | 2 | UniProt (P02281) Pfam (PF00125) | Xenopus laevis (African clawed frog) | H2B1.1 |
| 6 | K (X) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 328 | 37930.0 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (Human) | DOT1-like protein |
| 7 | L (Y) | Ubiquitin | polymer | 76 | 8576.8 | 1 | UniProt (P0CG47) Pfam (PF00240) | Homo sapiens (Human) | |
| 8 | M (X) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) |
Sequence modifications
D, H: 30 - 122 (UniProt: P02281)
| PDB | External Database | Details |
|---|---|---|
| Thr 29 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 206079.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 398.4 | |
| All* | Total formula weight | 206478.3 |
