6JMA
cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (I, J) | DNA I&J | polymer | 114 | 35168.5 | 2 | synthetic construct | ||
| 2 | C, G (A, E) | Histone H3.2 | polymer | 98 | 11488.4 | 2 | UniProt (P84233) Pfam (PF00125) | Xenopus laevis (African clawed frog) | |
| 3 | D, H (B, F) | Histone H4 | polymer | 87 | 9990.8 | 2 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 4 | E, I (C, G) | Histone H2A | polymer | 116 | 12660.7 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) | Xenopus laevis (African clawed frog) | |
| 5 | F, J (D, H) | Histone H2B 1.1 | polymer | 94 | 10478.0 | 2 | UniProt (P02281) Pfam (PF00125) | Xenopus laevis (African clawed frog) | H2B1.1 |
| 6 | K (X) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 328 | 37930.0 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (Human) | DOT1-like protein |
| 7 | L (Y) | Ubiquitin | polymer | 76 | 8576.8 | 1 | UniProt (P0CG47) Pfam (PF00240) | Homo sapiens (Human) | |
| 8 | M (X) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (9865603) PubChem (145712080) PubChem (12312798) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) |
Sequence modifications
D, H: 30 - 122 (UniProt: P02281)
| PDB | External Database | Details |
|---|---|---|
| Thr 29 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 206079.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 398.4 | |
| All* | Total formula weight | 206478.3 |
