5Y41

Crystal Structure of LIGAND-BOUND NURR1-LBD

Summary for 5Y41

Entry DOI	10.2210/pdb5y41/pdb
Descriptor	Nuclear receptor subfamily 4 group A member 2, (13E,15S)-15-hydroxy-9-oxoprosta-10,13-dien-1-oic acid, TRIETHYLENE GLYCOL, ... (7 entities in total)
Functional Keywords	nurr1, lbd, prostaglandin, transcription, michael addition
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	62176.95
Authors	Sreekanth, R.,Lescar, J.,Yoon, H.S. (deposition date: 2017-07-31, release date: 2018-12-26, Last modification date: 2023-11-22)
Primary citation	Rajan, S.,Jang, Y.,Kim, C.H.,Kim, W.,Toh, H.T.,Jeon, J.,Song, B.,Serra, A.,Lescar, J.,Yoo, J.Y.,Beldar, S.,Ye, H.,Kang, C.,Liu, X.W.,Feitosa, M.,Kim, Y.,Hwang, D.,Goh, G.,Lim, K.L.,Park, H.M.,Lee, C.H.,Oh, S.F.,Petsko, G.A.,Yoon, H.S.,Kim, K.S. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nat.Chem.Biol., 2020 Cited by PubMed: 32451509 DOI: 10.1038/s41589-020-0553-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation