5BOC

Crystal structure of topoisomerase ParE inhibitor

Summary for 5BOC

• Entry DOI: 10.2210/pdb5boc/pdb
• Related: 5BOD
• Descriptor: DNA topoisomerase 4 subunit B, 3-methyl-4-({3-[3-methyl-5-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)benzoic acid (3 entities in total)
• Functional Keywords: inhibitor, complex, topoisomerase, pare, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Streptococcus pneumoniae R6
• Total number of polymer chains: 1
• Total formula weight: 25004.08

Authors

Tan, Y.W.,Chen, G.Y.,Hung, A.W.,Hill, J. (deposition date: 2015-05-27, release date: 2015-06-17, Last modification date: 2023-11-08)

• Primary citation: Chen, G.Y.,Ng, F.M.,Tan, Y.W.,Poulsen, A.,Seetoh, W.,Lin, G.,Kang, C.,Then, S.W.,Ahmad, N.H.,Wong, Y.L.,Ng, H.,Chia, B.C.S.,Lau, Q.Y.,Hill, J.,Hung, A.W.,Keller, T.H.; Application of Fragment-based Drug Discovery against DNA GyraseB; To be published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)