7VB4

A crystal structure of alphavirus nonstructural protein 4 (nsP4) reveals an intrinsically dynamic RNA-dependent RNA polymerase

Summary for 7VB4

Entry DOI	10.2210/pdb7vb4/pdb
Descriptor	RNA-directed RNA polymerase nsP4, MAGNESIUM ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	rna dependent rna polymerase, rna directed rna polymerase, rdrp, alphavirus, nsp4, nonstructural protein 4, transferase
Biological source	Sindbis virus (SINV)
Total number of polymer chains	2
Total formula weight	117251.34
Authors	Tan, Y.B.,Luo, D. (deposition date: 2021-08-30, release date: 2022-02-16, Last modification date: 2023-11-29)
Primary citation	Tan, Y.B.,Lello, L.S.,Liu, X.,Law, Y.S.,Kang, C.,Lescar, J.,Zheng, J.,Merits, A.,Luo, D. Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Nucleic Acids Res., 50:1000-1016, 2022 Cited by PubMed: 35037043 DOI: 10.1093/nar/gkab1302 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation