6WDP
| Interleukin 12 receptor subunit beta-1 | 分子名称: | GLYCEROL, Interleukin-12 receptor subunit beta-1, SULFATE ION | 著者 | Spangler, J.B, Thomas, C, Jude, K.M, Garcia, K.C. | 登録日 | 2020-04-01 | 公開日 | 2021-02-24 | 最終更新日 | 2021-12-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell, 184, 2021
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6WDQ
| IL23/IL23R/IL12Rb1 signaling complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1, ... | 著者 | Jude, K.M, Ely, L.K, Glassman, C.R, Thomas, C, Spangler, J.B, Lupardus, P.J, Garcia, K.C. | 登録日 | 2020-04-01 | 公開日 | 2021-02-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell, 184, 2021
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6WEO
| IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Saxton, R.A, Jude, K.M, Henneberg, L.T, Garcia, K.C. | 登録日 | 2020-04-02 | 公開日 | 2021-04-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design. Immunity, 54, 2021
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1K8D
| crystal structure of the non-classical MHC class Ib Qa-2 complexed with a self peptide | 分子名称: | 60S RIBOSOMAL PROTEIN, BETA-2-MICROGLOBULIN, QA-2 antigen | 著者 | He, X, Tabaczewski, P, Ho, J, Stroynowski, I, Garcia, K.C. | 登録日 | 2001-10-23 | 公開日 | 2001-12-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation. Structure, 9, 2001
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6X93
| Interleukin-10 signaling complex with IL-10RA and IL-10RB | 分子名称: | Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta | 著者 | Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C. | 登録日 | 2020-06-02 | 公開日 | 2021-03-17 | 最終更新日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10. Science, 371, 2021
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1KZQ
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1LEK
| Crystal Structure of H-2Kbm3 bound to dEV8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | 著者 | Luz, J.G, Huang, M, Garcia, K.C, Rudolph, M.G, Apostolopoulos, V, Teyton, L, Wilson, I.A. | 登録日 | 2002-04-09 | 公開日 | 2002-06-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. J.Exp.Med., 195, 2002
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1LEG
| Crystal Structure of H-2Kb bound to the dEV8 peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-2-MICROGLOBULIN, ... | 著者 | Luz, J.G, Huang, M, Garcia, K.C, Rudolph, M.G, Apostolopoulos, V, Teyton, L, Wilson, I.A. | 登録日 | 2002-04-09 | 公開日 | 2002-06-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. J.Exp.Med., 195, 2002
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1MWA
| 2C/H-2KBM3/DEV8 ALLOGENEIC COMPLEX | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2C T CELL RECEPTOR ALPHA CHAIN, ... | 著者 | Luz, J.G, Huang, M.D, Garcia, K.C, Rudolph, M.G, Teyton, L, Wilson, I.A. | 登録日 | 2002-09-27 | 公開日 | 2002-11-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility
complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially
increasing V(beta) Interactions. J.EXP.MED., 195, 2002
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2B5I
| cytokine receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common gamma chain, ... | 著者 | Wang, X, Rickert, M, Garcia, K.C. | 登録日 | 2005-09-28 | 公開日 | 2005-11-29 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science, 310, 2005
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5E4E
| Engineered Interleukin-13 bound to receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13, Interleukin-13 receptor subunit alpha-1, ... | 著者 | Moraga, I, Thomas, C, Jude, K.M, Garcia, K.C. | 登録日 | 2015-10-05 | 公開日 | 2015-12-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency. Sci.Signal., 8, 2015
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5EO9
| Crystal Structure of the complex of Dpr6 Domain 1 bound to DIP-alpha Domain 1+2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CG32791, isoform A, ... | 著者 | Ozkan, E, Zinn, K, Garcia, K.C. | 登録日 | 2015-11-10 | 公開日 | 2016-01-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2988 Å) | 主引用文献 | Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins. Cell, 163, 2015
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7U7N
| IL-27 quaternary receptor signaling complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... | 著者 | Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C. | 登録日 | 2022-03-07 | 公開日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structure of the IL-27 quaternary receptor signaling complex. Elife, 11, 2022
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7TR4
| MA2-MART1-HLAA0201 | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA-A*02:01, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2022-01-27 | 公開日 | 2022-11-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy. Nat.Biotechnol., 41, 2023
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7UWJ
| Structure of the homodimeric IL-25-IL-17RB binary complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor B, Interleukin-25 | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-03 | 公開日 | 2022-07-27 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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7UWL
| Structure of the IL-25-IL-17RB-IL-17RA ternary complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-03 | 公開日 | 2022-07-27 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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7UWN
| Structure of the IL-17A-IL-17RA-IL-17RC ternary complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-03 | 公開日 | 2022-07-27 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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7UWM
| Structure of the IL-17A-IL-17RA binary complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-03 | 公開日 | 2022-07-27 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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7UWK
| Structure of the higher-order IL-25-IL-17RB complex | 分子名称: | Interleukin-17 receptor B, Interleukin-25 | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-03 | 公開日 | 2022-07-27 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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5IWL
| CD47-diabody complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5F9 diabody, Leukocyte surface antigen CD47, ... | 著者 | Di, W, Jude, K.M, Garcia, K.C. | 登録日 | 2016-03-22 | 公開日 | 2016-06-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J.Clin.Invest., 126, 2016
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4DEP
| Structure of the IL-1b signaling complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, Interleukin-1 receptor accessory protein, ... | 著者 | Thomas, C, Garcia, K.C. | 登録日 | 2012-01-21 | 公開日 | 2012-03-21 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the activating IL-1 receptor signaling complex. Nat.Struct.Mol.Biol., 19, 2012
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4F0A
| Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-8, PALMITOLEIC ACID, ... | 著者 | Janda, C.Y, Waghray, D, Levin, A.M, Thomas, C, Garcia, K.C. | 登録日 | 2012-05-03 | 公開日 | 2012-06-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structural basis of Wnt recognition by Frizzled. Science, 337, 2012
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4GAF
| Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EBI-005, Interleukin-1 receptor type 1, ... | 著者 | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | 登録日 | 2012-07-25 | 公開日 | 2013-02-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
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1P9M
| Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex | 分子名称: | Interleukin-6, Interleukin-6 receptor alpha chain, Interleukin-6 receptor beta chain | 著者 | Boulanger, M.J, Chow, D.C, Brevnova, E.E, Garcia, K.C. | 登録日 | 2003-05-12 | 公開日 | 2003-07-01 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex Science, 300, 2003
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1OZN
| 1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination | 分子名称: | ACETIC ACID, Reticulon 4 receptor, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | He, X, Bazan, J.F, Park, J.B, McDermott, G, He, Z, Garcia, K.C. | 登録日 | 2003-04-09 | 公開日 | 2003-05-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Structure of the Nogo Receptor Ectodomain. A Recognition module implicated in Myelin Inhibition. Neuron, 38, 2003
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