6WDQ

IL23/IL23R/IL12Rb1 signaling complex

Summary for 6WDQ

Entry DOI	10.2210/pdb6wdq/pdb
Descriptor	Interleukin-12 subunit beta, Interleukin-23 subunit alpha, Interleukin-23 receptor, ... (8 entities in total)
Functional Keywords	cytokine receptor, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	116493.50
Authors	Jude, K.M.,Ely, L.K.,Glassman, C.R.,Thomas, C.,Spangler, J.B.,Lupardus, P.J.,Garcia, K.C. (deposition date: 2020-04-01, release date: 2021-02-24, Last modification date: 2023-10-18)
Primary citation	Glassman, C.R.,Mathiharan, Y.K.,Jude, K.M.,Su, L.,Panova, O.,Lupardus, P.J.,Spangler, J.B.,Ely, L.K.,Thomas, C.,Skiniotis, G.,Garcia, K.C. Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell, 184:983-999.e24, 2021 Cited by PubMed: 33606986 DOI: 10.1016/j.cell.2021.01.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation