6WDQ
IL23/IL23R/IL12Rb1 signaling complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-12 subunit beta | polymer | 308 | 34910.2 | 1 | UniProt (P29460) Pfam (PF10420) | Homo sapiens (Human) | IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2 |
| 2 | B (B) | Interleukin-23 subunit alpha | polymer | 171 | 19099.6 | 1 | UniProt (Q9NPF7) Pfam (PF16649) | Homo sapiens (Human) | IL-23-A,Interleukin-23 subunit p19,IL-23p19 |
| 3 | C (C) | Interleukin-23 receptor | polymer | 307 | 35669.4 | 1 | UniProt (Q5VWK5) | Homo sapiens (Human) | IL-23R |
| 4 | D (D) | Interleukin-12 receptor subunit beta-1 | polymer | 219 | 24697.4 | 1 | UniProt (P42701) | Homo sapiens (Human) | IL-12RB1,IL-12 receptor beta component |
| 5 | E (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G, H, I, J, K (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 8 | L (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
B: 28 - 189 (UniProt: Q9NPF7)
C: 24 - 317 (UniProt: Q5VWK5)
D: 27 - 239 (UniProt: P42701)
| PDB | External Database | Details |
|---|---|---|
| Gly 190 | - | expression tag |
| Thr 191 | - | expression tag |
| Lys 192 | - | expression tag |
| His 193 | - | expression tag |
| His 194 | - | expression tag |
| His 195 | - | expression tag |
| His 196 | - | expression tag |
| His 197 | - | expression tag |
| His 198 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro 310 | Leu 310 | variant |
| Ile 318 | - | expression tag |
| Glu 319 | - | expression tag |
| Gly 320 | - | expression tag |
| Arg 321 | - | expression tag |
| Gly 322 | - | expression tag |
| Thr 323 | - | expression tag |
| Lys 324 | - | expression tag |
| His 325 | - | expression tag |
| His 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 240 | - | expression tag |
| His 241 | - | expression tag |
| His 242 | - | expression tag |
| His 243 | - | expression tag |
| His 244 | - | expression tag |
| His 245 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 114376.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1010.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1106.0 | |
| All* | Total formula weight | 116493.5 |
