6WDQ

IL23/IL23R/IL12Rb1 signaling complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Interleukin-12 subunit beta	polymer	308	34910.2	1	UniProt (P29460) Pfam (PF10420) In PDB	Homo sapiens (Human)	IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2
2	B	Interleukin-23 subunit alpha	polymer	171	19099.6	1	UniProt (Q9NPF7) Pfam (PF16649) In PDB	Homo sapiens (Human)	IL-23-A,Interleukin-23 subunit p19,IL-23p19
3	C	Interleukin-23 receptor	polymer	307	35669.4	1	UniProt (Q5VWK5) In PDB	Homo sapiens (Human)	IL-23R
4	D	Interleukin-12 receptor subunit beta-1	polymer	219	24697.4	1	UniProt (P42701) In PDB	Homo sapiens (Human)	IL-12RB1,IL-12 receptor beta component
5	E	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
6	F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	A, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
8		water	water		18.0	1	Chemie (HOH)

Sequence modifications

B: 28 - 189 (UniProt: Q9NPF7)

PDB	External Database	Details
Gly 190	-	expression tag
Thr 191	-	expression tag
Lys 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag
His 196	-	expression tag
His 197	-	expression tag
His 198	-	expression tag

C: 24 - 317 (UniProt: Q5VWK5)

PDB	External Database	Details
Pro 310	Leu 310	variant
Ile 318	-	expression tag
Glu 319	-	expression tag
Gly 320	-	expression tag
Arg 321	-	expression tag
Gly 322	-	expression tag
Thr 323	-	expression tag
Lys 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag

D: 27 - 239 (UniProt: P42701)

PDB	External Database	Details
His 240	-	expression tag
His 241	-	expression tag
His 242	-	expression tag
His 243	-	expression tag
His 244	-	expression tag
His 245	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	114376.5
Branched	Number of molecules	2
	Total formula weight	1010.9
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	116493.5

*Water molecules are not included.