4GAF

Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1

Summary for 4GAF

• Entry DOI: 10.2210/pdb4gaf/pdb
• Related: 4GAI
• Descriptor: EBI-005, Interleukin-1 receptor type 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: il-1beta, il-1ra, il-1r1, il-1 signaling, beta-trefoil, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 55368.89

Authors

Hou, J.,Townson, S.A.,Kovalchin, J.T.,Masci, A.,Kiner, O.,Shu, Y.,King, B.,Thomas, C.,Garcia, K.C.,Furfine, E.S.,Barnes, T.M. (deposition date: 2012-07-25, release date: 2013-02-20, Last modification date: 2020-07-29)

• Primary citation: Hou, J.,Townson, S.A.,Kovalchin, J.T.,Masci, A.,Kiner, O.,Shu, Y.,King, B.M.,Schirmer, E.,Golden, K.,Thomas, C.,Garcia, K.C.,Zarbis-Papastoitsis, G.,Furfine, E.S.,Barnes, T.M.; Design of a superior cytokine antagonist for topical ophthalmic use.; Proc.Natl.Acad.Sci.USA, 110:3913-3918, 2013; PubMed: 23431173; DOI: 10.1073/pnas.1217996110

Experimental method

X-RAY DIFFRACTION (2.15 Å)