4GAF

Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005615	cellular_component	extracellular space
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
B	0004908	molecular_function	interleukin-1 receptor activity
B	0004909	molecular_function	interleukin-1, type I, activating receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00253
Number of Residues	21
Details	INTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwFLCTameadqpV

Chain	Residue	Details
A	PHE111-VAL131

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Motif: {"description":"Involved in interaction with TMED10 C-terminus","evidences":[{"source":"PubMed","id":"32272059","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Involved in receptor binding"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"29030430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	92
Details	Domain: {"description":"Ig-like C2-type 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	102
Details	Domain: {"description":"Ig-like C2-type 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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