4F0A

Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8

Summary for 4F0A

• Entry DOI: 10.2210/pdb4f0a/pdb
• Related: 1IJY
• Descriptor: Frizzled-8, Protein Wnt-8, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: wnt signaling, ligand-receptor complex, wnt, frizzled, fatty acid acylation, glycosylation, signaling protein
• Biological source: Mus musculus (mouse); More
• Cellular location: Membrane; Multi-pass membrane protein: Q61091; Secreted, extracellular space, extracellular matrix: P28026
• Total number of polymer chains: 2
• Total formula weight: 52603.69

Authors

Janda, C.Y.,Waghray, D.,Levin, A.M.,Thomas, C.,Garcia, K.C. (deposition date: 2012-05-03, release date: 2012-06-13, Last modification date: 2020-07-29)

• Primary citation: Janda, C.Y.,Waghray, D.,Levin, A.M.,Thomas, C.,Garcia, K.C.; Structural basis of Wnt recognition by Frizzled.; Science, 337:59-64, 2012; PubMed: 22653731; DOI: 10.1126/science.1222879

Experimental method

X-RAY DIFFRACTION (3.25 Å)