4F0A
Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000578 | biological_process | embryonic axis specification |
| B | 0002020 | molecular_function | protease binding |
| B | 0003002 | biological_process | regionalization |
| B | 0005102 | molecular_function | signaling receptor binding |
| B | 0005109 | molecular_function | frizzled binding |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0007165 | biological_process | signal transduction |
| B | 0007275 | biological_process | multicellular organism development |
| B | 0007498 | biological_process | mesoderm development |
| B | 0009948 | biological_process | anterior/posterior axis specification |
| B | 0014034 | biological_process | neural crest cell fate commitment |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0030182 | biological_process | neuron differentiation |
| B | 0031012 | cellular_component | extracellular matrix |
| B | 0045165 | biological_process | cell fate commitment |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0060061 | biological_process | Spemann organizer formation |
| B | 0060070 | biological_process | canonical Wnt signaling pathway |
| B | 2000044 | biological_process | negative regulation of cardiac cell fate specification |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Region: {"description":"Wnt-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by tiki1 and tiki2","evidences":[{"source":"PubMed","id":"22726442","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"O-palmitoleoyl serine","evidences":[{"source":"PubMed","id":"22653731","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22653731","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F0A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
