4DEP
Structure of the IL-1b signaling complex
Summary for 4DEP
| Entry DOI | 10.2210/pdb4dep/pdb |
| Descriptor | Interleukin-1 beta, Interleukin-1 receptor type 1, Interleukin-1 receptor accessory protein, ... (5 entities in total) |
| Functional Keywords | b-trefoil, immunoglobulin, immune system, extracellular |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 6 |
| Total formula weight | 192862.82 |
| Authors | Thomas, C.,Garcia, K.C. (deposition date: 2012-01-21, release date: 2012-03-21, Last modification date: 2024-10-30) |
| Primary citation | Thomas, C.,Bazan, J.F.,Garcia, K.C. Structure of the activating IL-1 receptor signaling complex. Nat.Struct.Mol.Biol., 19:455-457, 2012 Cited by PubMed Abstract: Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1β bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family. PubMed: 22426547DOI: 10.1038/nsmb.2260 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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