4DEP

Structure of the IL-1b signaling complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005615	cellular_component	extracellular space
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
B	0004908	molecular_function	interleukin-1 receptor activity
B	0004909	molecular_function	interleukin-1, type I, activating receptor activity
C	0004908	molecular_function	interleukin-1 receptor activity
D	0005125	molecular_function	cytokine activity
D	0005615	cellular_component	extracellular space
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
E	0004908	molecular_function	interleukin-1 receptor activity
E	0004909	molecular_function	interleukin-1, type I, activating receptor activity
F	0004908	molecular_function	interleukin-1 receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00253
Number of Residues	21
Details	INTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwYISTsqaenmpV

Chain	Residue	Details
A	PHE112-VAL132

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	692
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
C	SER1-THR347
F	SER1-THR347

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site_id	SWS_FT_FI2
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN37
E	ASN232
E	ASN246
E	ASN280
C	ASN176
C	ASN279
F	ASN37
F	ASN176
F	ASN279
E	ASN83
E	ASN176
E	ASN216

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site_id	SWS_FT_FI3
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20802483

Chain	Residue	Details
C	ASN87
C	ASN91
C	ASN98
C	ASN189
F	ASN87
F	ASN91
F	ASN98
F	ASN189

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