4DEP

Structure of the IL-1b signaling complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Interleukin-1 beta	polymer	158	17807.3	2	UniProt (P01584) Pfam (PF00340)	Homo sapiens (human)	IL-1 beta, Catabolin
2	B, E (B, E)	Interleukin-1 receptor type 1	polymer	321	36968.0	2	UniProt (P14778) Pfam (PF18452) Pfam (PF13895)	Homo sapiens (human)	IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80
3	C, F (C, F)	Interleukin-1 receptor accessory protein	polymer	349	40107.7	2	UniProt (Q9NPH3) Pfam (PF18452)	Homo sapiens (human)	IL-1 receptor accessory protein, IL-1RAcP, Interleukin-1 receptor 3, IL-1R-3, IL-1R3
4	G, H, I, J, K... (B, C, E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	14	Chemie (NAG)
5	U, V, W (C, E, F)	water	water		18.0	7	Chemie (HOH)

Sequence modifications

A, D: 1 - 153 (UniProt: P01584)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B, E: 1 - 319 (UniProt: P14778)

PDB	External Database	Details
Glu -1	-	expression tag
Pro 0	-	expression tag

C, F: 1 - 347 (UniProt: Q9NPH3)

PDB	External Database	Details
Glu -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	189765.9
Non-Polymers*	Number of molecules	14
	Total formula weight	3096.9
All*	Total formula weight	192862.8

*Water molecules are not included.