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5DS4
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BU of 5ds4 by Molmil
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER)
Authors:Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A.
Deposit date:2015-09-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nature, 527, 2015
5E7J
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BU of 5e7j by Molmil
Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMP
Descriptor: ADENOSINE MONOPHOSPHATE, ATP-dependent RNA helicase DDX3X
Authors:Floor, S.N, Condon, K.J, Doudna, J.A.
Deposit date:2015-10-12
Release date:2015-12-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.
J.Biol.Chem., 291, 2016
5E7I
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BU of 5e7i by Molmil
Crystal structure of the active catalytic core of the human DEAD-box protein DDX3
Descriptor: ATP-dependent RNA helicase DDX3X
Authors:Floor, S.N, Condon, K.J, Doudna, J.A.
Deposit date:2015-10-12
Release date:2015-12-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.223 Å)
Cite:Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.
J.Biol.Chem., 291, 2016
5E7M
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BU of 5e7m by Molmil
Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMPPNP
Descriptor: ATP-dependent RNA helicase DDX3X, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Floor, S.N, Condon, K.J, Doudna, J.A.
Deposit date:2015-10-12
Release date:2015-12-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.
J.Biol.Chem., 291, 2016
5DS6
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BU of 5ds6 by Molmil
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA with splayed ends
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ...
Authors:Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A.
Deposit date:2015-09-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.352 Å)
Cite:Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nature, 527, 2015
5F9R
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BU of 5f9r by Molmil
Crystal structure of catalytically-active Streptococcus pyogenes CRISPR-Cas9 in complex with single-guided RNA and double-stranded DNA primed for target DNA cleavage
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (30-MER), DNA (5'-D(P*AP*TP*GP*AP*GP*AP*CP*GP*CP*TP*GP*GP*AP*GP*TP*AP*CP*AP*C)-3'), ...
Authors:Jiang, F, Doudna, J.A.
Deposit date:2015-12-10
Release date:2016-01-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.
Science, 351, 2016
8DC2
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BU of 8dc2 by Molmil
Cryo-EM structure of CasLambda (Cas12l) bound to crRNA and DNA
Descriptor: CasLambda, DNA NTS, DNA TS, ...
Authors:Al-Shayeb, B, Skopintsev, P, Soczek, K, Doudna, J.
Deposit date:2022-06-15
Release date:2022-12-14
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors.
Cell, 185, 2022
8FYA
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BU of 8fya by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex
Descriptor: Cas1, Cas2-DEDDh, DNA (28-MER), ...
Authors:Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
Deposit date:2023-01-25
Release date:2023-05-03
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
8FYD
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BU of 8fyd by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation
Descriptor: Cas1, Cas2-DEDDh, DNA (13-MER), ...
Authors:Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
Deposit date:2023-01-25
Release date:2023-05-03
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
8FY9
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BU of 8fy9 by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex
Descriptor: Cas1, Cas2-DEDDh, DNA (28-MER)
Authors:Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
Deposit date:2023-01-25
Release date:2023-05-03
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
8FYC
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BU of 8fyc by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation
Descriptor: Cas1, Cas2-DEDDh, DEDDh, ...
Authors:Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
Deposit date:2023-01-25
Release date:2023-05-03
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
8FYB
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BU of 8fyb by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex
Descriptor: Cas1, Cas2-DEDDh, DNA (17-MER), ...
Authors:Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
Deposit date:2023-01-25
Release date:2023-05-03
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
7LYS
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BU of 7lys by Molmil
Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and DNA
Descriptor: CasPhi-2, NTS-DNA, TS-DNA, ...
Authors:Pausch, P, Soczek, K, Nogales, E, Doudna, J.
Deposit date:2021-03-08
Release date:2021-08-04
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:DNA interference states of the hypercompact CRISPR-Cas Phi effector.
Nat.Struct.Mol.Biol., 28, 2021
7LYT
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BU of 7lyt by Molmil
Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and Phosphorothioate-DNA
Descriptor: CasPhi, MAGNESIUM ION, NTS-DNA*, ...
Authors:Pausch, P, Soczek, K, Nogales, E, Doudna, J.
Deposit date:2021-03-08
Release date:2021-08-04
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:DNA interference states of the hypercompact CRISPR-Cas Phi effector.
Nat.Struct.Mol.Biol., 28, 2021
7M5O
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BU of 7m5o by Molmil
Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA
Descriptor: CasPhi, ZINC ION, crRNA
Authors:Pausch, P, Soczek, K, Nogales, E, Doudna, J.
Deposit date:2021-03-24
Release date:2021-08-04
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:DNA interference states of the hypercompact CRISPR-Cas Phi effector.
Nat.Struct.Mol.Biol., 28, 2021
280D
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BU of 280d by Molmil
THE STRUCTURE OF AN RNA DODECAMER SHOWS HOW TANDEM U-U BASE PAIRS INCREASE THE RANGE OF STABLE RNA STRUCTURES AND THE DIVERSITY OF RECOGNITION SITES
Descriptor: RNA (5'-R(*GP*GP*CP*GP*CP*UP*UP*GP*CP*GP*UP*C)-3')
Authors:Lietzke, S.E, Barnes, C.L, Kundrot, C.E.
Deposit date:1996-08-22
Release date:1996-09-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of an RNA dodecamer shows how tandem U-U base pairs increase the range of stable RNA structures and the diversity of recognition sites.
Structure, 4, 1996
1HR2
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BU of 1hr2 by Molmil
CRYSTAL STRUCTURE ANALYSIS OF A MUTANT P4-P6 DOMAIN (DELC209) OF TETRAHYMENA THEMOPHILA GROUP I INTRON.
Descriptor: MAGNESIUM ION, P4-P6 DELC209 MUTANT RNA RIBOZYME DOMAIN
Authors:Juneau, K, Podell, E.R, Harrington, D.J, Cech, T.R.
Deposit date:2000-12-20
Release date:2001-04-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions.
Structure, 9, 2001
7WAY
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BU of 7way by Molmil
PlmCasX-sgRNAv1-dsDNA ternary complex at nts loading state
Descriptor: DNA (27-MER), DNA (33-MER), RNA, ...
Authors:Zhang, S, Liu, J.J.G.
Deposit date:2021-12-15
Release date:2022-03-16
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity.
Mol.Cell, 82, 2022
7WB1
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BU of 7wb1 by Molmil
PlmCasX-sgRNAv2-dsDNA ternary complex at nts loading state
Descriptor: NTS-DNA, RNA (121-MER), TS-DNA, ...
Authors:Zhang, S, Liu, J.J.G.
Deposit date:2021-12-15
Release date:2022-03-16
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity.
Mol.Cell, 82, 2022
7WAZ
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BU of 7waz by Molmil
PlmCasX-sgRNAv1-dsDNA ternary complex at ts loading state
Descriptor: NTS-DNA, RNA (115-MER), TS-DNA, ...
Authors:Zhang, S, Liu, J.J.G.
Deposit date:2021-12-15
Release date:2022-03-16
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity.
Mol.Cell, 82, 2022
7WB0
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BU of 7wb0 by Molmil
PlmCasX-sgRNAv1-dsDNA ternary complex at nts loading state with flexible H2 domain
Descriptor: NTS-DNA, RNA (115-MER), TS-DNA, ...
Authors:Zhang, S, Liu, J.J.G.
Deposit date:2021-12-15
Release date:2022-03-16
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity.
Mol.Cell, 82, 2022
5L1Z
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BU of 5l1z by Molmil
TAR complex with HIV-1 Tat-AFF4-P-TEFb
Descriptor: AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ...
Authors:Schulze-Gahmen, U, Hurley, J.
Deposit date:2016-07-29
Release date:2016-10-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (5.9 Å)
Cite:Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.
Elife, 5, 2016
3GOD
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BU of 3god by Molmil
Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated antiviral defense
Descriptor: CALCIUM ION, Cas1, MANGANESE (II) ION, ...
Authors:Wiedenheft, B.
Deposit date:2009-03-18
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense.
Structure, 17, 2009
3LQX
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BU of 3lqx by Molmil
SRP ribonucleoprotein core complexed with cobalt hexammine
Descriptor: CHLORIDE ION, COBALT HEXAMMINE(III), POTASSIUM ION, ...
Authors:Batey, R.T.
Deposit date:2010-02-10
Release date:2010-03-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural and Energetic Analysis of Metal Ions Essential to SRP Signal Recognition Domain Assembly
Biochemistry, 41, 2002
6O1O
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BU of 6o1o by Molmil
Cryo-EM structure of the T. thermophilus Csm complex bound to target ssRNA
Descriptor: Csm1, Csm2, Csm3, ...
Authors:Liu, J.J, Liu, T.Y.
Deposit date:2019-02-21
Release date:2019-07-10
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble.
Nat Commun, 10, 2019

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