2KNH
 
 | | The Solution structure of the eTAFH domain of AML1-ETO complexed with HEB peptide | | Descriptor: | Protein CBFA2T1, Transcription factor 12 | | Authors: | Park, S, Cierpicki, T, Tonelli, M, Bushweller, J.H. | | Deposit date: | 2009-08-25 | | Release date: | 2009-10-06 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
Blood, 113, 2009
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2KYG
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8WA3
 | | Cryo-EM structure of peptide free and Gs-coupled GIPR | | Descriptor: | Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... | | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | Deposit date: | 2023-09-06 | | Release date: | 2024-03-06 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
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8WG8
 | | Cryo-EM structures of peptide free and Gs-coupled GCGR | | Descriptor: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | Deposit date: | 2023-09-20 | | Release date: | 2024-03-06 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.71 Å) | | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
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8WG7
 | | Cryo-EM structures of peptide free and Gs-coupled GLP-1R | | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | Deposit date: | 2023-09-20 | | Release date: | 2024-03-06 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
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7VQK
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8GY7
 | | Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein | | Descriptor: | CALCIUM ION, Corticotropin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Luo, P, Feng, W.B, Ma, S.S, Dai, A.T, Yuan, Q.N, Wu, K, Yang, D.H, Wang, M.W, Xu, H.E, Jiang, Y. | | Deposit date: | 2022-09-21 | | Release date: | 2023-01-11 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1.
Cell Res., 33, 2023
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8UF5
 | | Catalytic domain of GtfB in complex with inhibitor G43 | | Descriptor: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | | Authors: | Schormann, N, Deivanayagam, C, Velu, S. | | Deposit date: | 2023-10-03 | | Release date: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence.
Sci Rep, 7, 2017
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7EZK
 | | Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gs complex | | Descriptor: | Chimera of Guanine nucleotide-binding protein G(i) subunit alpha-1 and Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Cholecystokinin receptor type A, Cholecystokinin-8, ... | | Authors: | Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. | | Deposit date: | 2021-06-01 | | Release date: | 2021-08-25 | | Last modified: | 2022-06-29 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Nat.Chem.Biol., 17, 2021
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7EZM
 | | Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex | | Descriptor: | Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. | | Deposit date: | 2021-06-01 | | Release date: | 2021-08-25 | | Last modified: | 2022-06-29 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Nat.Chem.Biol., 17, 2021
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7EZH
 | | Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex | | Descriptor: | Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. | | Deposit date: | 2021-06-01 | | Release date: | 2021-08-25 | | Last modified: | 2022-06-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Nat.Chem.Biol., 17, 2021
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7W7V
 | | 'late' E2P of SERCA2b | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | | Authors: | Zhang, Y, Watanabe, S, Tsutsumi, A, Inaba, K. | | Deposit date: | 2021-12-06 | | Release date: | 2022-12-14 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Multiple sub-state structures of SERCA2b reveal conformational overlap at transition steps during the catalytic cycle.
Cell Rep, 41, 2022
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7W7U
 | | The 'Ca2+-unbound' BeF3- of SERCA2b | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | | Authors: | Zhang, Y, Watanabe, S, Tsutsumi, A, Inaba, K. | | Deposit date: | 2021-12-06 | | Release date: | 2022-12-14 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Multiple sub-state structures of SERCA2b reveal conformational overlap at transition steps during the catalytic cycle.
Cell Rep, 41, 2022
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7W7W
 | | E2 Pi of SERCA2b | | Descriptor: | MAGNESIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, TETRAFLUOROALUMINATE ION | | Authors: | Zhang, Y, Watanabe, S, Tsutsumi, A, Inaba, K. | | Deposit date: | 2021-12-06 | | Release date: | 2022-12-14 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Multiple sub-state structures of SERCA2b reveal conformational overlap at transition steps during the catalytic cycle.
Cell Rep, 41, 2022
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7W7T
 | | The E1-BeF3- 2Ca2+ of SERCA2b | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, CALCIUM ION, MAGNESIUM ION, ... | | Authors: | Zhang, Y, Watanabe, S, Tsutsumi, A, Inaba, K. | | Deposit date: | 2021-12-06 | | Release date: | 2022-12-14 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Multiple sub-state structures of SERCA2b reveal conformational overlap at transition steps during the catalytic cycle.
Cell Rep, 41, 2022
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7E3L
 | | Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 58G6 heavy chain, 58G6 light chain, ... | | Authors: | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | | Deposit date: | 2021-02-09 | | Release date: | 2021-09-15 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.
Nat Commun, 12, 2021
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7E3K
 | | Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | | Descriptor: | 13G9 heavy chain, 13G9 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | | Deposit date: | 2021-02-09 | | Release date: | 2021-09-15 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.
Nat Commun, 12, 2021
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7E9G
 | | Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2 | | Descriptor: | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one, DN13, ... | | Authors: | Lin, S, Han, S, Zhao, Q, Wu, B. | | Deposit date: | 2021-03-04 | | Release date: | 2021-06-23 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4.
Nature, 594, 2021
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7E9H
 | | Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu4 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ... | | Authors: | Lin, S, Han, S, Zhao, Q, Wu, B. | | Deposit date: | 2021-03-04 | | Release date: | 2021-06-23 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4.
Nature, 594, 2021
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7CBZ
 | | Crystal structure of T2R-TTL-A31 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[5-[4-[2-[4-(2-cyclopropylethanoyl)piperazin-1-yl]ethoxy]phenyl]pyridin-2-yl]-N-(phenylmethyl)ethanamide, CALCIUM ION, ... | | Authors: | Yang, J.H, Yan, W. | | Deposit date: | 2020-06-15 | | Release date: | 2021-06-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure.
J.Med.Chem., 64, 2021
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7CT5
 | | S protein of SARS-CoV-2 in complex bound with T-ACE2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | | Authors: | Guo, L, Bi, W.W, Zhang, Y.Y, Yan, R.H, Li, Y.N, Zhou, Q, Dang, B.B. | | Deposit date: | 2020-08-18 | | Release date: | 2020-11-18 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection.
Cell Res., 31, 2021
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7C53
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6LY5
 | | Organization and energy transfer in a huge diatom PSI-FCPI supercomplex | | Descriptor: | (3S,3'R,5R,6S,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol, (3S,3'S,5R,5'R,6S,6'R,8'R)-3,5'-dihydroxy-8-oxo-6',7'-didehydro-5,5',6,6',7,8-hexahydro-5,6-epoxy-beta,beta-caroten-3'- yl acetate, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ... | | Authors: | Xiong, P, Caizhe, X. | | Deposit date: | 2020-02-13 | | Release date: | 2020-10-21 | | Method: | ELECTRON MICROSCOPY (2.38 Å) | | Cite: | Structural basis for energy transfer in a huge diatom PSI-FCPI supercomplex.
Nat Commun, 11, 2020
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