8JPE

Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes

Summary for 8JPE

Entry DOI	10.2210/pdb8jpe/pdb
EMDB information	36477
Descriptor	Guanine nucleotide-binding protein G(q) subunit alpha, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	biased signaling, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41853.38
Authors	Duan, J.,Liu, H.,Zhao, F.,Yuan, Q.,Ji, Y.,Xu, H.E. (deposition date: 2023-06-11, release date: 2023-08-09, Last modification date: 2023-08-30)
Primary citation	Duan, J.,Liu, H.,Zhao, F.,Yuan, Q.,Ji, Y.,Cai, X.,He, X.,Li, X.,Li, J.,Wu, K.,Gao, T.,Zhu, S.,Lin, S.,Wang, M.W.,Cheng, X.,Yin, W.,Jiang, Y.,Yang, D.,Xu, H.E. GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620:676-681, 2023 Cited by PubMed: 37532940 DOI: 10.1038/s41586-023-06395-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.91 Å)

Structure validation