8JPE

Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes

Functional Information from GO Data

Chain	GOid	namespace	contents
Q	0000166	molecular_function	nucleotide binding
Q	0001664	molecular_function	G protein-coupled receptor binding
Q	0001750	cellular_component	photoreceptor outer segment
Q	0003924	molecular_function	GTPase activity
Q	0003925	molecular_function	G protein activity
Q	0005096	molecular_function	GTPase activator activity
Q	0005515	molecular_function	protein binding
Q	0005525	molecular_function	GTP binding
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005765	cellular_component	lysosomal membrane
Q	0005794	cellular_component	Golgi apparatus
Q	0005834	cellular_component	heterotrimeric G-protein complex
Q	0005886	cellular_component	plasma membrane
Q	0007165	biological_process	signal transduction
Q	0007186	biological_process	G protein-coupled receptor signaling pathway
Q	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
Q	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
Q	0007206	biological_process	phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
Q	0007208	biological_process	phospholipase C-activating serotonin receptor signaling pathway
Q	0007209	biological_process	phospholipase C-activating tachykinin receptor signaling pathway
Q	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
Q	0007215	biological_process	glutamate receptor signaling pathway
Q	0007218	biological_process	neuropeptide signaling pathway
Q	0007596	biological_process	blood coagulation
Q	0007603	biological_process	phototransduction, visible light
Q	0009649	biological_process	entrainment of circadian clock
Q	0009755	biological_process	hormone-mediated signaling pathway
Q	0009898	cellular_component	cytoplasmic side of plasma membrane
Q	0010543	biological_process	regulation of platelet activation
Q	0016787	molecular_function	hydrolase activity
Q	0019001	molecular_function	guanyl nucleotide binding
Q	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
Q	0031965	cellular_component	nuclear membrane
Q	0032278	biological_process	positive regulation of gonadotropin secretion
Q	0034695	biological_process	response to prostaglandin E
Q	0042593	biological_process	glucose homeostasis
Q	0043303	biological_process	mast cell degranulation
Q	0046872	molecular_function	metal ion binding
Q	0050821	biological_process	protein stabilization
Q	0060828	biological_process	regulation of canonical Wnt signaling pathway
Q	0070062	cellular_component	extracellular exosome
Q	0071468	biological_process	cellular response to acidic pH
Q	0099524	cellular_component	postsynaptic cytosol
Q	0160025	biological_process	sensory perception of itch
Q	1904181	biological_process	positive regulation of membrane depolarization

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P21279","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Deamidated glutamine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---