The Solution structure of the eTAFH domain of AML1-ETO complexed with HEB peptide

Summary for 2KNH

DescriptorProtein CBFA2T1, Transcription factor 12 (2 entities in total)
Functional Keywordsaml1-eto, etafh, heb, dna-binding, metal-binding, nucleus, proto-oncogene, transcription, transcription regulation, zinc-finger, developmental protein, phosphoprotein, transcription regulator
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight13613.66
Park, S.,Cierpicki, T.,Tonelli, M.,Bushweller, J.H. (deposition date: 2009-08-25, release date: 2009-10-06, Last modification date: 2020-02-26)
Primary citation
Park, S.,Chen, W.,Cierpicki, T.,Tonelli, M.,Cai, X.,Speck, N.A.,Bushweller, J.H.
Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
Blood, 113:3558-3567, 2009
PubMed: 19204326 (PDB entries with the same primary citation)
DOI: 10.1182/blood-2008-06-161307
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers88 0.3% 34.6%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload