7CBZ

Crystal structure of T2R-TTL-A31 complex

Summary for 7CBZ

Entry DOI	10.2210/pdb7cbz/pdb
Descriptor	Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, Tubulin beta chain, ... (11 entities in total)
Functional Keywords	tubulin, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological source	Sus scrofa (Pig) More
Total number of polymer chains	6
Total formula weight	270289.60
Authors	Yang, J.H.,Yan, W. (deposition date: 2020-06-15, release date: 2021-06-23, Last modification date: 2023-11-29)
Primary citation	Wang, L.,Zheng, Y.,Li, D.,Yang, J.,Lei, L.,Yan, W.,Zheng, W.,Tang, M.,Shi, M.,Zhang, R.,Cai, X.,Ni, H.,Ma, X.,Li, N.,Hong, F.,Ye, H.,Chen, L. Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure. J.Med.Chem., 64:8127-8141, 2021 Cited by PubMed: 34081857 DOI: 10.1021/acs.jmedchem.0c01961 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation