7CBZ

Crystal structure of T2R-TTL-A31 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Tubulin alpha-1B chain	polymer	451	50204.4	2	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (Pig)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2	B, D (B, D)	Tubulin beta chain	polymer	445	49999.9	2	UniProt (P02554) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (Pig)	Beta-tubulin
3	E (E)	Stathmin-4	polymer	189	22125.3	1	UniProt (P63043) Pfam (PF00836)	Rattus norvegicus (Rat)	Stathmin-like protein B3,RB3
4	F (F)	Tubulin tyrosine ligase	polymer	383	44240.4	1	UniProt (E1BQ43)	Gallus gallus (Chicken)
5	G, Q (A, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	H, L, R, U, X (A, B, C, D, F)	MAGNESIUM ION	non-polymer		24.3	5	Chemie (MG)
7	I, J, N, O, S... (A, B, C, D)	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
8	K, T (B, D)	2-[5-[4-[2-[4-(2-cyclopropylethanoyl)piperazin-1-yl]ethoxy]phenyl]pyridin-2-yl]-N-(phenylmethyl)ethanamide	non-polymer		512.6	2	Chemie (FUO)
9	M (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
10	P, W (B, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
11	AA, BA, CA, DA, Y... (C, D, E, F, A...)	water	water		18.0	116	Chemie (HOH)

Sequence modifications

B, D: 1 - 447 (UniProt: P02554)

PDB	External Database	Details
Thr 57	Ala 55	conflict
Met 172	Val 170	conflict
Ser 298	Ala 296	conflict
Ile 318	Val 316	conflict

F: 1 - 378 (UniProt: E1BQ43)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	266774.3
Non-Polymers*	Number of molecules	18
	Total formula weight	3515.3
All*	Total formula weight	270289.6

*Water molecules are not included.