8JPC

cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2

Summary for 8JPC

Entry DOI	10.2210/pdb8jpc/pdb
EMDB information	36475
Descriptor	NTS(8-13), Neurotensin receptor type 1, Beta-adrenergic receptor kinase 1, ... (9 entities in total)
Functional Keywords	biased signaling, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	169541.78
Authors	Duan, J.,Liu, H.,Zhao, F.,Yuan, Q.,Ji, Y.,Xu, H.E. (deposition date: 2023-06-11, release date: 2023-08-09, Last modification date: 2023-08-30)
Primary citation	Duan, J.,Liu, H.,Zhao, F.,Yuan, Q.,Ji, Y.,Cai, X.,He, X.,Li, X.,Li, J.,Wu, K.,Gao, T.,Zhu, S.,Lin, S.,Wang, M.W.,Cheng, X.,Yin, W.,Jiang, Y.,Yang, D.,Xu, H.E. GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620:676-681, 2023 Cited by PubMed: 37532940 DOI: 10.1038/s41586-023-06395-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.07 Å)

Structure validation