8WG7

Cryo-EM structures of peptide free and Gs-coupled GLP-1R

Summary for 8WG7

Entry DOI	10.2210/pdb8wg7/pdb
EMDB information	37504
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
Functional Keywords	g protein-coupled receptor, ligand recognition, receptor activation, unimolecular agonist, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	158517.81
Authors	Cong, Z.T.,Zhao, F.H.,Li, Y.,Luo, G.,Zhou, Q.T.,Yang, D.H.,Wang, M.W. (deposition date: 2023-09-20, release date: 2024-03-06)
Primary citation	Cong, Z.,Zhao, F.,Li, Y.,Luo, G.,Mai, Y.,Chen, X.,Chen, Y.,Lin, S.,Cai, X.,Zhou, Q.,Yang, D.,Wang, M.W. Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10:18-18, 2024 Cited by PubMed: 38346960 DOI: 10.1038/s41421-024-00649-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.54 Å)

Structure validation