7C53

Crystal Structure of SARS-CoV-2 HR1 motif in complex with pan-CoVs inhibitor EK1

Summary for 7C53

• Entry DOI: 10.2210/pdb7c53/pdb
• Descriptor: Spike protein S2',pan-CoVs inhibitor EK1, CALCIUM ION (3 entities in total)
• Functional Keywords: sars-cov-2 hr1, pan-covs inhibitor, ek1 peptide, virus, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 6
• Total formula weight: 70040.53

Authors

Zhu, Y.,Yang, X.,Sun, F. (deposition date: 2020-05-19, release date: 2021-05-19, Last modification date: 2023-11-29)

• Primary citation: Xia, S.,Lan, Q.,Zhu, Y.,Wang, C.,Xu, W.,Li, Y.,Wang, L.,Jiao, F.,Zhou, J.,Hua, C.,Wang, Q.,Cai, X.,Wu, Y.,Gao, J.,Liu, H.,Sun, G.,Munch, J.,Kirchhoff, F.,Yuan, Z.,Xie, Y.,Sun, F.,Jiang, S.,Lu, L.; Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation.; Signal Transduct Target Ther, 6:288-288, 2021; PubMed: 34326308; DOI: 10.1038/s41392-021-00712-2

Experimental method

X-RAY DIFFRACTION (2.278 Å)