8JPD

Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes

Summary for 8JPD

Entry DOI	10.2210/pdb8jpd/pdb
EMDB information	36476
Descriptor	Beta-adrenergic receptor kinase 1, STAUROSPORINE (2 entities in total)
Functional Keywords	biased signaling, signaling protein
Biological source	Bos taurus (cattle)
Total number of polymer chains	1
Total formula weight	80111.26
Authors	Duan, J.,Liu, H.,Zhao, F.,Yuan, Q.,Ji, Y.,Xu, H.E. (deposition date: 2023-06-11, release date: 2023-08-09, Last modification date: 2023-08-30)
Primary citation	Duan, J.,Liu, H.,Zhao, F.,Yuan, Q.,Ji, Y.,Cai, X.,He, X.,Li, X.,Li, J.,Wu, K.,Gao, T.,Zhu, S.,Lin, S.,Wang, M.W.,Cheng, X.,Yin, W.,Jiang, Y.,Yang, D.,Xu, H.E. GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620:676-681, 2023 Cited by PubMed: 37532940 DOI: 10.1038/s41586-023-06395-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.81 Å)

Structure validation