8JPD

Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0000166	molecular_function	nucleotide binding
G	0001664	molecular_function	G protein-coupled receptor binding
G	0002026	biological_process	regulation of the force of heart contraction
G	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
G	0002031	biological_process	G protein-coupled receptor internalization
G	0003108	biological_process	negative regulation of the force of heart contraction by chemical signal
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004703	molecular_function	G protein-coupled receptor kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006468	biological_process	protein phosphorylation
G	0006886	biological_process	intracellular protein transport
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
G	0007217	biological_process	tachykinin receptor signaling pathway
G	0009966	biological_process	regulation of signal transduction
G	0016020	cellular_component	membrane
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0019079	biological_process	viral genome replication
G	0031623	biological_process	receptor internalization
G	0031694	molecular_function	alpha-2A adrenergic receptor binding
G	0031755	molecular_function	Edg-2 lysophosphatidic acid receptor binding
G	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
G	0045880	biological_process	positive regulation of smoothened signaling pathway
G	0045988	biological_process	negative regulation of striated muscle contraction
G	0046718	biological_process	symbiont entry into host cell
G	0047696	molecular_function	beta-adrenergic receptor kinase activity
G	0060048	biological_process	cardiac muscle contraction
G	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
G	0098793	cellular_component	presynapse
G	0098794	cellular_component	postsynapse
G	1901081	biological_process	negative regulation of relaxation of smooth muscle
G	1903566	biological_process	positive regulation of protein localization to cilium

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK

Chain	Residue	Details
G	ILE197-LYS220

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL

Chain	Residue	Details
G	VAL313-LEU325

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	121
Details	Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	262
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	67
Details	Domain: {"description":"AGC-kinase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00618","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	94
Details	Domain: {"description":"PH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00145","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Site: {"description":"Required for receptor phosphorylation","evidences":[{"source":"UniProtKB","id":"P25098","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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