8JPF

Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes

Summary for 8JPF

• Entry DOI: 10.2210/pdb8jpf/pdb
• EMDB information: 36478
• Descriptor: NTS, Neurotensin receptor type 1, 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (3 entities in total)
• Functional Keywords: biased signaling, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 47577.15

Authors

Duan, J.,Liu, H.,Zhao, F.,Yuan, Q.,Ji, Y.,Xu, H.E. (deposition date: 2023-06-11, release date: 2023-08-09, Last modification date: 2023-08-30)

• Primary citation: Duan, J.,Liu, H.,Zhao, F.,Yuan, Q.,Ji, Y.,Cai, X.,He, X.,Li, X.,Li, J.,Wu, K.,Gao, T.,Zhu, S.,Lin, S.,Wang, M.W.,Cheng, X.,Yin, W.,Jiang, Y.,Yang, D.,Xu, H.E.; GPCR activation and GRK2 assembly by a biased intracellular agonist.; Nature, 620:676-681, 2023; PubMed: 37532940; DOI: 10.1038/s41586-023-06395-9

Experimental method

ELECTRON MICROSCOPY (3.02 Å)