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8JPF

Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes

Functional Information from GO Data
ChainGOidnamespacecontents
R0001659biological_processtemperature homeostasis
R0003085biological_processnegative regulation of systemic arterial blood pressure
R0003254biological_processregulation of membrane depolarization
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005783cellular_componentendoplasmic reticulum
R0005794cellular_componentGolgi apparatus
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007218biological_processneuropeptide signaling pathway
R0007268biological_processchemical synaptic transmission
R0007612biological_processlearning
R0008344biological_processadult locomotory behavior
R0009898cellular_componentcytoplasmic side of plasma membrane
R0009986cellular_componentcell surface
R0010628biological_processpositive regulation of gene expression
R0014049biological_processpositive regulation of glutamate secretion
R0014054biological_processpositive regulation of gamma-aminobutyric acid secretion
R0016020cellular_componentmembrane
R0016492molecular_functionG protein-coupled neurotensin receptor activity
R0030424cellular_componentaxon
R0030425cellular_componentdendrite
R0032280cellular_componentsymmetric synapse
R0033993biological_processresponse to lipid
R0042802molecular_functionidentical protein binding
R0043025cellular_componentneuronal cell body
R0043065biological_processpositive regulation of apoptotic process
R0043066biological_processnegative regulation of apoptotic process
R0043195cellular_componentterminal bouton
R0043197cellular_componentdendritic spine
R0043198cellular_componentdendritic shaft
R0043204cellular_componentperikaryon
R0043576biological_processregulation of respiratory gaseous exchange
R0043679cellular_componentaxon terminus
R0044309cellular_componentneuron spine
R0044877molecular_functionprotein-containing complex binding
R0045121cellular_componentmembrane raft
R0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
R0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
R0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
R0060732biological_processpositive regulation of inositol phosphate biosynthetic process
R0070779biological_processD-aspartate import across plasma membrane
R0071545biological_processinositol phosphate catabolic process
R0090238biological_processpositive regulation of arachidonic acid secretion
R0097151biological_processpositive regulation of inhibitory postsynaptic potential
R0098712biological_processL-glutamate import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ATAlNVASLSVERYLaI
ChainResidueDetails
RALA154-ILE170

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues130
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P20789
ChainResidueDetails
RMET1-THR67
RGLU123-ARG142
RTHR206-LYS234
RPHE326-HIS343

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250|UniProtKB:P20789
ChainResidueDetails
RALA68-LEU88

site_idSWS_FT_FI3
Number of Residues128
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P20789
ChainResidueDetails
RALA89-HIS102
RGLU165-ARG184
RALA260-ARG303
RASN365-TYR418

site_idSWS_FT_FI4
Number of Residues19
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250|UniProtKB:P20789
ChainResidueDetails
RTYR103-VAL122

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250|UniProtKB:P20789
ChainResidueDetails
RGLY143-VAL164

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:P20789
ChainResidueDetails
RTHR185-PHE205

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:P20789
ChainResidueDetails
RVAL235-ILE259

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:P20789
ChainResidueDetails
RVAL304-MET325

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:P20789
ChainResidueDetails
RTYR344-TYR364

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:21725197
ChainResidueDetails
RCYS381
RCYS383

site_idSWS_FT_FI11
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN4
RASN37
RASN41

224004

PDB entries from 2024-08-21

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