8EQ5
| Crystal structure of the N-terminal kinase domain of RSK2 in complex with SPRED2 (131-160) | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, Ribosomal protein S6 kinase alpha-3, Sprouty-related, ... | 著者 | Bonsor, D.A, Lopez, J, McCormick, F, Simanshu, D.K. | 登録日 | 2022-10-07 | 公開日 | 2023-04-26 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. J.Biol.Chem., 299, 2023
|
|
6VC8
| Crystal structure of wild-type KRAS4b(1-169) in complex with GMPPNP and Mg ion | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Tran, T.H, Davies, D.R, Edwards, T.E, Simanshu, D.K. | 登録日 | 2019-12-20 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8U1M
| |
8U1L
| |
8U1N
| |
1NF1
| THE GAP RELATED DOMAIN OF NEUROFIBROMIN | 分子名称: | PROTEIN (NEUROFIBROMIN) | 著者 | Scheffzek, K, Ahmadian, M.R, Wiesmueller, L, Kabsch, W, Stege, P, Schmitz, F, Wittinghofer, A. | 登録日 | 1998-07-08 | 公開日 | 1999-07-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural analysis of the GAP-related domain from neurofibromin and its implications. EMBO J., 17, 1998
|
|
1WER
| RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP | 分子名称: | P120GAP | 著者 | Scheffzek, K, Lautwein, A, Kabsch, W, Ahmadian, M.R, Wittinghofer, A. | 登録日 | 1996-11-20 | 公開日 | 1997-12-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. Nature, 384, 1996
|
|
6P0Z
| Crystal structure of N-acetylated KRAS (2-169) bound to GDP and Mg | 分子名称: | ACETYL GROUP, DI(HYDROXYETHYL)ETHER, GTPase KRas, ... | 著者 | Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. | 登録日 | 2019-05-17 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.011 Å) | 主引用文献 | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
|
|
6OB2
| Crystal structure of wild-type KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1) | 分子名称: | CHLORIDE ION, GLYCEROL, GTPase KRas, ... | 著者 | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2019-03-19 | 公開日 | 2019-10-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.845 Å) | 主引用文献 | KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6V65
| |
6V6F
| |
6VJJ
| Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-01-16 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
|
|
8E20
| |
8EBZ
| |
8EPW
| Crystal Structure of KRAS4b-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2022-10-06 | 公開日 | 2023-06-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D . Commun Biol, 6, 2023
|
|
8EDM
| |
6MBT
| Crystal structure of wild-type KRAS bound to GDP and Mg (Space group C2) | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. | 登録日 | 2018-08-30 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
|
|
6MBQ
| Crystal structure of Mg-free wild-type KRAS (2-166) bound to GMPPNP in the state 1 conformation | 分子名称: | 1,2-ETHANEDIOL, GTPase KRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Dharmaiah, S, Davies, D.R, Abendroth, J, Gillette, W.G, Stephen, A.G, Simanshu, D.K. | 登録日 | 2018-08-30 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
|
|
6M9W
| Structure of Mg-free KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE | 著者 | Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. | 登録日 | 2018-08-24 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
|
|
6MBU
| Crystal structure of wild-type KRAS (1-169) bound to GDP and Mg (Space group P3) | 分子名称: | GLYCEROL, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. | 登録日 | 2018-08-30 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
|
|
6OB3
| Crystal structure of G13D-KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, GTPase KRas, ... | 著者 | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2019-03-19 | 公開日 | 2019-10-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
5TAR
| Crystal structure of farnesylated and methylated kras4b in complex with PDE-delta (crystal form II - with ordered hypervariable region) | 分子名称: | 1,2-ETHANEDIOL, FARNESYL, GTPase KRas, ... | 著者 | Dharmaiah, S, Tran, T.H, Simanshu, D.K. | 登録日 | 2016-09-10 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5TB5
| Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region) | 分子名称: | 1,2-ETHANEDIOL, FARNESYL, GTPase KRas, ... | 著者 | Dharmaiah, S, Tran, T.H, Simanshu, D.K. | 登録日 | 2016-09-11 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
7T7A
| Crystal Structure of Human SHOC2: A Leucine-Rich Repeat Protein | 分子名称: | Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, NITRATE ION | 著者 | Hajian, B, Lemke, C, Kwon, J, Bian, Y, Fuller, C, Aguirre, J. | 登録日 | 2021-12-14 | 公開日 | 2022-05-04 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature, 609, 2022
|
|
7TVG
| |