6OB2

Crystal structure of wild-type KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1)

Summary for 6OB2

Entry DOI	10.2210/pdb6ob2/pdb
Descriptor	GTPase KRas, Neurofibromin, GLYCEROL, ... (8 entities in total)
Functional Keywords	kras, ras, kras4b, nf1, gap, neurofibromin, gtp binding-lipid binding complex, gtp binding/lipid binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	98523.05
Authors	Tran, T.H.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2019-03-19, release date: 2019-10-16, Last modification date: 2023-10-11)
Primary citation	Rabara, D.,Tran, T.H.,Dharmaiah, S.,Stephens, R.M.,McCormick, F.,Simanshu, D.K.,Holderfield, M. KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 116:22122-22131, 2019 Cited by PubMed: 31611389 DOI: 10.1073/pnas.1908353116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.845 Å)

Structure validation