6OB2
Crystal structure of wild-type KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003924 | molecular_function | GTPase activity |
A | 0005525 | molecular_function | GTP binding |
A | 0007165 | biological_process | signal transduction |
A | 0016020 | cellular_component | membrane |
B | 0043087 | biological_process | regulation of GTPase activity |
C | 0003924 | molecular_function | GTPase activity |
C | 0005525 | molecular_function | GTP binding |
C | 0007165 | biological_process | signal transduction |
C | 0016020 | cellular_component | membrane |
D | 0043087 | biological_process | regulation of GTPase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue GOL A 201 |
Chain | Residue |
A | ASP154 |
A | ARG161 |
B | MET1225 |
B | ALA1226 |
B | ASN1229 |
site_id | AC2 |
Number of Residues | 26 |
Details | binding site for residue GNP A 202 |
Chain | Residue |
A | LYS16 |
A | SER17 |
A | ALA18 |
A | PHE28 |
A | VAL29 |
A | ASP30 |
A | GLU31 |
A | PRO34 |
A | THR35 |
A | GLY60 |
A | ASN116 |
A | LYS117 |
A | ASP119 |
A | LEU120 |
A | SER145 |
A | ALA146 |
A | LYS147 |
A | MG203 |
A | HOH303 |
A | HOH304 |
A | HOH305 |
A | HOH308 |
A | GLY12 |
A | GLY13 |
A | VAL14 |
A | GLY15 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue MG A 203 |
Chain | Residue |
A | SER17 |
A | THR35 |
A | GNP202 |
A | HOH304 |
A | HOH305 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue GOL B 1501 |
Chain | Residue |
A | MET67 |
A | GLN70 |
B | VAL1398 |
B | SER1399 |
B | LYS1409 |
B | GLU1415 |
B | LYS1419 |
site_id | AC5 |
Number of Residues | 22 |
Details | binding site for residue GNP C 201 |
Chain | Residue |
C | GLY12 |
C | GLY13 |
C | VAL14 |
C | GLY15 |
C | LYS16 |
C | SER17 |
C | ALA18 |
C | PHE28 |
C | VAL29 |
C | ASP30 |
C | PRO34 |
C | THR35 |
C | GLY60 |
C | ASN116 |
C | LYS117 |
C | ASP119 |
C | SER145 |
C | ALA146 |
C | LYS147 |
C | MG202 |
C | HOH301 |
C | HOH302 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue MG C 202 |
Chain | Residue |
C | SER17 |
C | THR35 |
C | GNP201 |
C | HOH301 |
C | HOH302 |
Functional Information from PROSITE/UniProt
site_id | PS00509 |
Number of Residues | 15 |
Details | RAS_GTPASE_ACTIV_1 Ras GTPase-activating proteins (rasGAP) domain signature. SaMFLRFINPAIVSP |
Chain | Residue | Details |
B | SER1386-PRO1400 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | Motif: {"description":"Effector region"} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 36 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | Site: {"description":"Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state","evidences":[{"source":"PROSITE-ProRule","id":"PRU00167","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |