6OB2
Crystal structure of wild-type KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | GTPase KRas | polymer | 170 | 19328.8 | 2 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
2 | B, D | Neurofibromin | polymer | 256 | 29241.8 | 2 | UniProt (P21359) Pfam (PF00616) In PDB | Homo sapiens (Human) | Neurofibromatosis-related protein NF-1 |
3 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | A, C | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
5 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | B | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
7 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
8 | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 169 (UniProt: P01116)
B, D: 1209 - 1463 (UniProt: P21359)
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 1208 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 97141.3 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1381.7 | |
All* | Total formula weight | 98523.0 |