6OB2
Crystal structure of wild-type KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | GTPase KRas | polymer | 170 | 19328.8 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B, D (B, D) | Neurofibromin | polymer | 256 | 29241.8 | 2 | UniProt (P21359) Pfam (PF00616) | Homo sapiens (Human) | Neurofibromatosis-related protein NF-1 |
| 3 | E, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | F, K (A, C) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
| 5 | G, L (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | I (B) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 7 | J (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 169 (UniProt: P01116)
B, D: 1209 - 1463 (UniProt: P21359)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 1208 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97141.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1381.7 | |
| All* | Total formula weight | 98523.0 |
