8U1L

Cryo-EM structure of the RAF1-HSP90-CDC37 complex in the closed state

Summary for 8U1L

• Entry DOI: 10.2210/pdb8u1l/pdb
• EMDB information: 41816 41817 41818
• Descriptor: Heat shock protein 83, RAF proto-oncogene serine/threonine-protein kinase, Hsp90 co-chaperone Cdc37, N-terminally processed, ... (5 entities in total)
• Functional Keywords: craf, raf1, hsp90, cdc37, signaling protein-chaperone complex, signaling protein/chaperone
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 286351.05

Authors

Finci, L.I.,Simanshu, D.K. (deposition date: 2023-09-01, release date: 2024-03-13)

• Primary citation: Finci, L.I.,Chakrabarti, M.,Gulten, G.,Finney, J.,Grose, C.,Fox, T.,Yang, R.,Nissley, D.V.,McCormick, F.,Esposito, D.,Balius, T.E.,Simanshu, D.K.; Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements.; Commun Biol, 7:260-260, 2024; PubMed: 38431713; DOI: 10.1038/s42003-024-05959-3

Experimental method

ELECTRON MICROSCOPY (3.7 Å)