8U1L
Cryo-EM structure of the RAF1-HSP90-CDC37 complex in the closed state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heat shock protein 83 | polymer | 722 | 83322.1 | 2 | UniProt (A0A7E5VSK5) Pfam (PF13589) Pfam (PF00183) | Trichoplusia ni (cabbage looper) | |
| 2 | C (C) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 656 | 74021.4 | 1 | UniProt (P04049) Pfam (PF02196) Pfam (PF00130) Pfam (PF00069) | Homo sapiens (human) | |
| 3 | D (D) | Hsp90 co-chaperone Cdc37, N-terminally processed | polymer | 378 | 44622.4 | 1 | UniProt (Q16543) Pfam (PF03234) Pfam (PF08565) Pfam (PF08564) | Homo sapiens (human) | |
| 4 | E, G (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
C: 2 - 648 (UniProt: P04049)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 649 | - | expression tag |
| His 650 | - | expression tag |
| His 651 | - | expression tag |
| His 652 | - | expression tag |
| His 653 | - | expression tag |
| His 654 | - | expression tag |
| His 655 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 285288.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1063.0 | |
| All* | Total formula weight | 286351.0 |
