8E20
Cryo-EM structure of the full-length human NF1 dimer
Summary for 8E20
| Entry DOI | 10.2210/pdb8e20/pdb |
| EMDB information | 27826 |
| Descriptor | Isoform I of Neurofibromin (1 entity in total) |
| Functional Keywords | gtpase activating protein, ras signaling, cancer, signaling protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 634821.62 |
| Authors | Darling, J.E.,Merk, A.,Grisshammer, R.,Ognjenovic, J. (deposition date: 2022-08-12, release date: 2023-04-26) |
| Primary citation | Young, L.C.,Goldstein de Salazar, R.,Han, S.W.,Huang, Z.Y.S.,Merk, A.,Drew, M.,Darling, J.,Wall, V.,Grisshammer, R.,Cheng, A.,Allison, M.R.,Sale, M.J.,Nissley, D.V.,Esposito, D.,Ognjenovic, J.,McCormick, F. Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proc.Natl.Acad.Sci.USA, 120:e2208960120-e2208960120, 2023 Cited by PubMed: 36689660DOI: 10.1073/pnas.2208960120 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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