5TB5
Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region)
Summary for 5TB5
Entry DOI | 10.2210/pdb5tb5/pdb |
Descriptor | GTPase KRas, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, FARNESYL, ... (6 entities in total) |
Functional Keywords | kras4b, pdedelta, pde6delta, ras, kras, oncoprotein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 Cytoplasm, cytosol : O43924 |
Total number of polymer chains | 4 |
Total formula weight | 78417.26 |
Authors | Dharmaiah, S.,Tran, T.H.,Simanshu, D.K. (deposition date: 2016-09-11, release date: 2016-11-02, Last modification date: 2023-10-04) |
Primary citation | Dharmaiah, S.,Bindu, L.,Tran, T.H.,Gillette, W.K.,Frank, P.H.,Ghirlando, R.,Nissley, D.V.,Esposito, D.,McCormick, F.,Stephen, A.G.,Simanshu, D.K. Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta. Proc.Natl.Acad.Sci.USA, 113:E6766-E6775, 2016 Cited by PubMed: 27791178DOI: 10.1073/pnas.1615316113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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