5TB5
Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | GTPase KRas | polymer | 185 | 21056.0 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B, D (B, D) | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | polymer | 150 | 17441.0 | 2 | UniProt (O43924) Pfam (PF05351) | Homo sapiens (Human) | GMP-PDE delta,Protein p17 |
| 3 | E, H (A, C) | FARNESYL | non-polymer | 206.4 | 2 | Chemie (FAR) PubChem (21734683) PubChem (22820188) PubChem (56993491) PubChem (444108) PubChem (4475483) PubChem (13619421) PubChem (158605953) | |||
| 4 | F, I (A, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 5 | G, J (B, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A, C: 2 - 185 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 76994.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1423.3 | |
| All* | Total formula weight | 78417.3 |
