5TB5
Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | GTPase KRas | polymer | 185 | 21056.0 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B, D (B, D) | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | polymer | 150 | 17441.0 | 2 | UniProt (O43924) Pfam (PF05351) | Homo sapiens (Human) | GMP-PDE delta,Protein p17 |
| 3 | E, H (A, C) | FARNESYL | non-polymer | 206.4 | 2 | Chemie (FAR) | |||
| 4 | F, I (A, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 5 | G, J (B, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A, C: 2 - 185 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 76994.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1423.3 | |
| All* | Total formula weight | 78417.3 |
