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5TB5

Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0001889biological_processliver development
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0007165biological_processsignal transduction
A0007265biological_processRas protein signal transduction
A0007565biological_processfemale pregnancy
A0008283biological_processcell population proliferation
A0008542biological_processvisual learning
A0009629biological_processresponse to gravity
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010467biological_processgene expression
A0010628biological_processpositive regulation of gene expression
A0012505cellular_componentendomembrane system
A0014009biological_processglial cell proliferation
A0016020cellular_componentmembrane
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019002molecular_functionGMP binding
A0019003molecular_functionGDP binding
A0019221biological_processcytokine-mediated signaling pathway
A0021897biological_processforebrain astrocyte development
A0030036biological_processactin cytoskeleton organization
A0030275molecular_functionLRR domain binding
A0030857biological_processnegative regulation of epithelial cell differentiation
A0032228biological_processregulation of synaptic transmission, GABAergic
A0035022biological_processpositive regulation of Rac protein signal transduction
A0035900biological_processresponse to isolation stress
A0035914biological_processskeletal muscle cell differentiation
A0043495molecular_functionprotein-membrane adaptor activity
A0043524biological_processnegative regulation of neuron apoptotic process
A0044877molecular_functionprotein-containing complex binding
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048873biological_processhomeostasis of number of cells within a tissue
A0051146biological_processstriated muscle cell differentiation
A0051384biological_processresponse to glucocorticoid
A0051385biological_processresponse to mineralocorticoid
A0051402biological_processneuron apoptotic process
A0051450biological_processmyoblast proliferation
A0060038biological_processcardiac muscle cell proliferation
A0060252biological_processpositive regulation of glial cell proliferation
A0060441biological_processepithelial tube branching involved in lung morphogenesis
A0060509biological_processtype I pneumocyte differentiation
A2000774biological_processpositive regulation of cellular senescence
B0005095molecular_functionGTPase inhibitor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005929cellular_componentcilium
B0007601biological_processvisual perception
B0030659cellular_componentcytoplasmic vesicle membrane
B0031267molecular_functionsmall GTPase binding
B0031410cellular_componentcytoplasmic vesicle
B0050953biological_processsensory perception of light stimulus
C0000139cellular_componentGolgi membrane
C0000165biological_processMAPK cascade
C0000166molecular_functionnucleotide binding
C0001889biological_processliver development
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005741cellular_componentmitochondrial outer membrane
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0007165biological_processsignal transduction
C0007265biological_processRas protein signal transduction
C0007565biological_processfemale pregnancy
C0008283biological_processcell population proliferation
C0008542biological_processvisual learning
C0009629biological_processresponse to gravity
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010467biological_processgene expression
C0010628biological_processpositive regulation of gene expression
C0012505cellular_componentendomembrane system
C0014009biological_processglial cell proliferation
C0016020cellular_componentmembrane
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019002molecular_functionGMP binding
C0019003molecular_functionGDP binding
C0019221biological_processcytokine-mediated signaling pathway
C0021897biological_processforebrain astrocyte development
C0030036biological_processactin cytoskeleton organization
C0030275molecular_functionLRR domain binding
C0030857biological_processnegative regulation of epithelial cell differentiation
C0032228biological_processregulation of synaptic transmission, GABAergic
C0035022biological_processpositive regulation of Rac protein signal transduction
C0035900biological_processresponse to isolation stress
C0035914biological_processskeletal muscle cell differentiation
C0043495molecular_functionprotein-membrane adaptor activity
C0043524biological_processnegative regulation of neuron apoptotic process
C0044877molecular_functionprotein-containing complex binding
C0048169biological_processregulation of long-term neuronal synaptic plasticity
C0048873biological_processhomeostasis of number of cells within a tissue
C0051146biological_processstriated muscle cell differentiation
C0051384biological_processresponse to glucocorticoid
C0051385biological_processresponse to mineralocorticoid
C0051402biological_processneuron apoptotic process
C0051450biological_processmyoblast proliferation
C0060038biological_processcardiac muscle cell proliferation
C0060252biological_processpositive regulation of glial cell proliferation
C0060441biological_processepithelial tube branching involved in lung morphogenesis
C0060509biological_processtype I pneumocyte differentiation
C2000774biological_processpositive regulation of cellular senescence
D0005095molecular_functionGTPase inhibitor activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005929cellular_componentcilium
D0007601biological_processvisual perception
D0030659cellular_componentcytoplasmic vesicle membrane
D0031267molecular_functionsmall GTPase binding
D0031410cellular_componentcytoplasmic vesicle
D0050953biological_processsensory perception of light stimulus
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue FAR A 201
ChainResidue
ALYS184
ACMT185
BSER39
BLEU63
BGLN78
BTHR131
BPHE133

site_idAC2
Number of Residues17
Detailsbinding site for residue GDP A 202
ChainResidue
AGLY15
ALYS16
ASER17
AALA18
APHE28
AASN116
ALYS117
AASP119
ALEU120
ASER145
AALA146
ALYS147
AHOH319
AHOH345
AHOH348
AGLY13
AVAL14

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO B 201
ChainResidue
BARG61
BLEU63
BPHE92
BTRP105
BSER107

site_idAC4
Number of Residues9
Detailsbinding site for residue FAR C 201
ChainResidue
CLYS184
CCMT185
DMET20
DLEU22
DSER39
DLEU76
DGLN78
DTHR131
DPHE133

site_idAC5
Number of Residues18
Detailsbinding site for residue GDP C 202
ChainResidue
CALA11
CGLY13
CVAL14
CGLY15
CLYS16
CSER17
CALA18
CPHE28
CASP30
CALA59
CASN116
CLYS117
CASP119
CLEU120
CSER145
CALA146
CLYS147
CHOH303

site_idAC6
Number of Residues5
Detailsbinding site for residue EDO D 201
ChainResidue
DARG61
DLEU63
DPHE92
DTRP105
DSER107

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues12
DetailsRegion: {"description":"Required for association with membranes","evidences":[{"source":"PubMed","id":"9712853","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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