6OB3

Crystal structure of G13D-KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1)

Summary for 6OB3

Entry DOI	10.2210/pdb6ob3/pdb
Descriptor	GTPase KRas, Neurofibromin, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (7 entities in total)
Functional Keywords	kras, ras, kras4b, nf1, gap, neurofibromin, g13d, signaling protein-gtp binding complex, signaling protein/gtp binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	99432.94
Authors	Tran, T.H.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2019-03-19, release date: 2019-10-16, Last modification date: 2023-10-11)
Primary citation	Rabara, D.,Tran, T.H.,Dharmaiah, S.,Stephens, R.M.,McCormick, F.,Simanshu, D.K.,Holderfield, M. KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 116:22122-22131, 2019 Cited by PubMed: 31611389 DOI: 10.1073/pnas.1908353116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation