6OB3
Crystal structure of G13D-KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | GTPase KRas | polymer | 170 | 19386.8 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B, D (B, D) | Neurofibromin | polymer | 256 | 29241.8 | 2 | UniProt (P21359) Pfam (PF00616) | Homo sapiens (Human) | Neurofibromatosis-related protein NF-1 |
| 3 | E, L (A, C) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
| 4 | F, M (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | G, H, N (B, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 6 | I, J, K, O, P (B, D) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 5 | Chemie (MES) | |||
| 7 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 169 (UniProt: P01116)
B, D: 1209 - 1463 (UniProt: P21359)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Asp 13 | Gly 13 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 1208 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97257.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2175.5 | |
| All* | Total formula weight | 99432.9 |
