7TVG

Crystal Structure of SHOC2 to a resolution of 2.4 Angstrom

Summary for 7TVG

Entry DOI	10.2210/pdb7tvg/pdb
Descriptor	Leucine-rich repeat protein SHOC-2, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	scaffold protein adapter protein leucine rich repeat oncoprotein, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	57276.11
Authors	Bonsor, D.A.,Simanshu, D.K. (deposition date: 2022-02-04, release date: 2022-05-04, Last modification date: 2022-10-26)
Primary citation	Bonsor, D.A.,Alexander, P.,Snead, K.,Hartig, N.,Drew, M.,Messing, S.,Finci, L.I.,Nissley, D.V.,McCormick, F.,Esposito, D.,Rodriguez-Viciana, P.,Stephen, A.G.,Simanshu, D.K. Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nat.Struct.Mol.Biol., 29:966-977, 2022 Cited by PubMed: 36175670 DOI: 10.1038/s41594-022-00841-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation