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6QD4
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BU of 6qd4 by Molmil
MloK1 model from single particle analysis of 2D crystals, class 8 (intermediate conformation)
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H.
Deposit date:2018-12-31
Release date:2019-04-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.
Nat Commun, 10, 2019
6QD0
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BU of 6qd0 by Molmil
MloK1 model from single particle analysis of 2D crystals, class 4 (compact/open conformation)
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H.
Deposit date:2018-12-31
Release date:2019-04-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.
Nat Commun, 10, 2019
8PHW
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BU of 8phw by Molmil
Human OATP1B1
Descriptor: CHOLESTEROL HEMISUCCINATE, Fab18 (heavy chain, variable region), ...
Authors:Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P.
Deposit date:2023-06-20
Release date:2023-09-27
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
8PG0
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BU of 8pg0 by Molmil
Human OATP1B3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ...
Authors:Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P.
Deposit date:2023-06-17
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
8PMD
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BU of 8pmd by Molmil
Nucleotide-bound BSEP in nanodiscs
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, MAGNESIUM ION
Authors:Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P.
Deposit date:2023-06-28
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
8PM6
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BU of 8pm6 by Molmil
Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs
Descriptor: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Bile salt export pump, CHOLESTEROL
Authors:Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P.
Deposit date:2023-06-28
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
8PMJ
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BU of 8pmj by Molmil
Vanadate-trapped BSEP in nanodiscs
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, ...
Authors:Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P.
Deposit date:2023-06-28
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
7OJ8
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BU of 7oj8 by Molmil
ABCG2 E1S turnover-2 state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ...
Authors:Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P.
Deposit date:2021-05-14
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
7OJH
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BU of 7ojh by Molmil
ABCG2 topotecan turnover-1 state
Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ...
Authors:Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P.
Deposit date:2021-05-15
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
7OJI
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BU of 7oji by Molmil
ABCG2 topotecan turnover-2 state
Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ...
Authors:Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P.
Deposit date:2021-05-16
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
6ETI
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BU of 6eti by Molmil
Structure of inhibitor-bound ABCG2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
Authors:Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P.
Deposit date:2017-10-26
Release date:2018-04-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
6FFC
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BU of 6ffc by Molmil
Structure of an inhibitor-bound ABC transporter
Descriptor: ATP-binding cassette sub-family G member 2, ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
Authors:Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P.
Deposit date:2018-01-06
Release date:2018-04-11
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
6FEQ
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BU of 6feq by Molmil
Structure of inhibitor-bound ABCG2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
Authors:Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P.
Deposit date:2018-01-03
Release date:2018-04-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
8AGB
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BU of 8agb by Molmil
Structure of yeast oligosaccharylransferase complex with lipid-linked oligosaccharide bound
Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ramirez, A.S, de Capitani, M, Pesciullesi, G, Kowal, J, Bloch, J.S, Irobalieva, R.N, Aebi, M, Reymond, J.L, Locher, K.P.
Deposit date:2022-07-19
Release date:2022-12-07
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.
Nat Commun, 13, 2022
8AGC
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BU of 8agc by Molmil
Structure of yeast oligosaccharylransferase complex with lipid-linked oligosaccharide and non-acceptor peptide bound
Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ramirez, A.S, de Capitani, M, Pesciullesi, G, Kowal, J, Bloch, J.S, Irobalieva, R.N, Aebi, M, Reymond, J.L, Locher, K.P.
Deposit date:2022-07-19
Release date:2022-12-07
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.
Nat Commun, 13, 2022
8AGE
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BU of 8age by Molmil
Structure of yeast oligosaccharylransferase complex with acceptor peptide bound
Descriptor: (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ...
Authors:Ramirez, A.S, de Capitani, M, Pesciullesi, G, Kowal, J, Bloch, J.S, Irobalieva, R.N, Aebi, M, Reymond, J.L, Locher, K.P.
Deposit date:2022-07-19
Release date:2022-12-07
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.
Nat Commun, 13, 2022
8BHT
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BU of 8bht by Molmil
ABCG2 turnover-1 state with tariquidar bound
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ...
Authors:Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P.
Deposit date:2022-10-31
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2.
Proc.Natl.Acad.Sci.USA, 120, 2023
8BI0
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BU of 8bi0 by Molmil
ABCG2 turnover-2 state with tariquidar bound
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ...
Authors:Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P.
Deposit date:2022-11-01
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2.
Proc.Natl.Acad.Sci.USA, 120, 2023
6HIJ
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BU of 6hij by Molmil
Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked
Descriptor: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ATP-binding cassette sub-family G member 2, CHOLESTEROL, ...
Authors:Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P.
Deposit date:2018-08-30
Release date:2018-09-19
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat.Struct.Mol.Biol., 25, 2018
6HZM
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BU of 6hzm by Molmil
Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium (alternative placement of Magnesium into the cryo-EM density)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family G member 2, MAGNESIUM ION
Authors:Manolaridis, I, Jackson, S.M, Taylor, N.M.I, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2018-10-23
Release date:2018-11-14
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Nature, 563, 2018
6HBU
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BU of 6hbu by Molmil
Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family G member 2, MAGNESIUM ION
Authors:Manolaridis, I, Jackson, S.M, Taylor, N.M.I, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2018-08-13
Release date:2018-11-07
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Nature, 563, 2018
6HCO
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BU of 6hco by Molmil
Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ...
Authors:Manolaridis, I, Jackson, S.M, Taylor, N.M.I, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2018-08-15
Release date:2018-11-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Nature, 563, 2018
2N5E
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BU of 2n5e by Molmil
The 3D solution structure of discoidal high-density lipoprotein particles
Descriptor: Apolipoprotein A-I
Authors:Bibow, S, Polyhach, Y, Eichmann, C, Chi, C.N, Kowal, J, Stahlberg, H, Jeschke, G, Guentert, P, Riek, R.
Deposit date:2015-07-15
Release date:2016-12-21
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.
Nat.Struct.Mol.Biol., 24, 2017
5SSY
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BU of 5ssy by Molmil
Crystal Structure of human formylglycine generating enzyme
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (I) ION, ...
Authors:Radhakrishnan, K, Schlotawa, L, Rudolph, M.G.
Deposit date:2022-08-12
Release date:2023-08-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Crystal Structure of human formylglycine generating enzyme in complex with N-acetyl-cysteine methylester
To be published
5SSX
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BU of 5ssx by Molmil
Crystal Structure human formylglycine generating enzyme E130D mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (I) ION, ...
Authors:Radhakrishnan, K, Schlotawa, L, Rudolph, M.G.
Deposit date:2022-08-12
Release date:2023-08-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Crystal Structure of human formylglycine generating enzyme E130D mutant
To be published

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PDB entries from 2024-06-12

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