6HCO

Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab

Summary for 6HCO

Entry DOI	10.2210/pdb6hco/pdb
EMDB information	0190 0196
Descriptor	ATP-binding cassette sub-family G member 2, 5D3-Fab light chain, 5D3-Fab heavy chain, ... (5 entities in total)
Functional Keywords	multidrug transporter, membrane protein, cancer
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	242864.05
Authors	Manolaridis, I.,Jackson, S.M.,Taylor, N.M.I.,Kowal, J.,Stahlberg, H.,Locher, K.P. (deposition date: 2018-08-15, release date: 2018-11-07, Last modification date: 2020-07-29)
Primary citation	Manolaridis, I.,Jackson, S.M.,Taylor, N.M.I.,Kowal, J.,Stahlberg, H.,Locher, K.P. Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature, 563:426-430, 2018 Cited by PubMed: 30405239 DOI: 10.1038/s41586-018-0680-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.58 Å)

Structure validation